Publications by authors named "Raksha P Indorkar"
Impact of dopamine-glutamate interactions on striatal neuronal nitric oxide synthase activity.
Psychopharmacology (Berl)
January 2010
Rationale: It is known that dopamine (DA) D1 receptor activation stimulates striatal nitric oxide (NO) synthesis, whereas D2 receptor activation produces the opposite effect. However, the mechanisms involved in the dopaminergic modulation of nitric oxide synthase (NOS) are unknown.
Objectives: We hypothesized that the effects of DA on striatal NO signaling are dependent on ongoing glutamatergic activation of NOS.
Article Synopsis
- Nitric oxide is a key gaseous neurotransmitter that modulates synaptic transmission between the cortex and striatum in the brain.
- Stimulation of the frontal cortex led to increased nitric oxide release and changes in neuronal activity, with certain inhibitors affecting spontaneous and stimulated neural spikes.
- The findings suggest that nitric oxide signaling counteracts dopamine receptor-mediated inhibition, highlighting its role in how striatal networks process sensorimotor information.