High Prevalence of Found in Ticks Collected in Barnaul, Altai Krai, Western Siberia.

The prevalence of the tick-borne spotted fever group rickettsioses pathogens in ticks collected in Barnaul, the administrative center of Altai Krai, Western Siberia, was studied. The causative agent of tick-borne lymphadenopathy (TIBOLA) was revealed to be present in 61.9% of the samples from ticks.

Antibiotic Resistance and Plasmid Profile Analysis of Enteritidis Isolated in Siberia and the Far East of Russia between 1990 and 2017.

is one of the major causes of foodborne disease outbreaks globally. Specifically, subsp. serovar Enteritidis ( Enteritidis) is one of the major causes of zoonotic infection in humans worldwide.

Increased Production of Outer Membrane Vesicles by Salmonella Interferes with Complement-Mediated Innate Immune Attack.

Bacterial outer membrane vesicles (OMVs) enriched with bioactive proteins, toxins, and virulence factors play a critical role in host-pathogen and microbial interactions. The two-component system PhoP-PhoQ (PhoPQ) of Salmonella enterica orchestrates the remodeling of outer membrane lipopolysaccharide (LPS) molecules and concomitantly upregulates OMV production. In this study, we document a novel use of nanoparticle tracking analysis to determine bacterial OMV size and number.

Isolating SARS-CoV-2 Strains From Countries in the Same Meridian: Genome Evolutionary Analysis.

Background: COVID-19, caused by the novel SARS-CoV-2, is considered the most threatening respiratory infection in the world, with over 40 million people infected and over 0.934 million related deaths reported worldwide. It is speculated that epidemiological and clinical features of COVID-19 may differ across countries or continents.

Genetic diversity of subsp. serovar Enteritidis in the Siberia and Far East of Russia based on plasmid profiles.

For the first time, in the literature review we presents the molecular genetic structure of Enteritidis populations in Russia, and particularly, in Siberia and the Far East of the country. Pathogen population in Russia has been compared with populations circulating in different countries of the world. It has been shown that the microbial population is heterogeneous, but it is possible to identify the dominant and main genotypes, which determine up to 90% of the total population morbidity.

The Not so Good, the Bad and the Ugly: Differential Bacterial Adhesion and Invasion Mediated by PagN Allelic Variants.

While advances in genomic sequencing have highlighted significant strain variability between and within serovars, only a few protein variants have been directly related to evolutionary adaptation for survival, such as host specificity or differential virulence. The current study investigated whether allelic variation of the adhesin/invasin PagN influences bacterial interaction with their receptors. The serovar Typhi ( Typhi) allelic variant of PagN was found to bind significantly better to different enterocytes as well as to the extracellular matrix protein laminin than did the major serovar Typhimurium ( Typhimurium) allele.

Interaction of Salmonella enteritidis and Salmonella typhimurium in Microbial Association Formed by Them in In Vitro Experiment.

We studied the interaction of Salmonella enteritidis and Salmonella typhimurium in the microbial association formed by these microorganisms in vitro. It was found that S. typhimurium in microbial association in LB-broth inhibited reproduction of S.

Association of Salmonella virulence factor alleles with intestinal and invasive serovars.

Background: The role of Salmonella virulence factor (VF) allelic variation in modulating pathogenesis or host specificity has only been demonstrated in a few cases, mostly through serendipitous findings. Virulence factor (VF) alleles from Salmonella enterica subsp. enterica genomes were compared to identify potential associations with the host-adapted invasive serovars Typhi, Dublin, Choleraesuis, and Gallinarum, and with the broad host-range intestinal serovars Typhimurium, Enteritidis, and Newport.

Cooperation of Adhesin Alleles in -Host Tropism.

Allelic combinations and host specificities for three fimbrial adhesins, FimH, BcfD, and StfH, were compared for 262 strains of serovar Newport, a frequent human and livestock pathogen. Like FimH, BcfD had two major alleles (designated A and B), whereas StfH had two allelic groups, each with two alleles (subgroup A1 and A2 and subgroup B1 and B2). The most prevalent combinations of FimH/BcfD/StfH alleles in .

[FORMATION OF POPULATION MORBIDITY WITH SALMONELLOSIS CAUSED BY SALMONELLA ENTERITIDIS IN REGIONS WITH INCOMPLETE SUPPLY OF LOCAL POULTRY PRODUCTS].

Aim: Study plasmid characteristics of S. enteritidis strains in patients and features of epidemi- ology of the infection in regions with incomplete supply of population with local poultry produc- tion.

Materials And Methods: Plasmid analysis of microbe strains isolated from 382 patients and 8 samples of products was carried out, and significance of plasmid types in population morbidity was evaluated.

[An analysis of the work of vascular service in Smolensk from 2009 to 2014].

Material And Methods: Report of the regional vascular service center of Smolensk work and work of vascular service of Smolensk region were analyzed. The aim of the study is to analyze work of the vascular service in Smolensk and Smolensk region in 2009-2014.

Results And Conclusion: Mortality and morbidity in patients with cardio-vascular diseases in Smolensk Region are higher than in other regions of Russia.

Molecular characterization of Streptococcus pneumoniae serotype 12F isolates associated with rural community outbreaks in Alaska.

Outbreaks of invasive pneumococcal disease (IPD) caused by Streptococcus pneumoniae serotype 12F were observed in two neighboring regions of rural Alaska in 2003 to 2006 and 2006 to 2008. IPD surveillance data from 1986 to 2009 and carriage survey data from 1998 to 2004 and 2008 to 2009 were reviewed to identify patterns of serotype 12F transmission. Pulsed-field gel electrophoresis was performed on all available isolates, and selected isolates were characterized by additional genetic subtyping methods.

Heart rate variability in conscious and anesthetized rats under the action of angiotensin converting enzyme inhibitors.

We studied the effects of three various angiotensin converting enzyme inhibitors (enalapril, lisinopril and quinapril) on heart rhythm variability in anesthetized and immobilized rats. In all cases (except for quinapril in experiments on anesthetized animals), the preparations reduced the total rhythm variability and, according to spectrum analysis, increased activity of the parasympathetic autonomic nervous system to different degrees and decreased sympathetic tone. Quinapril and lisinopril produced the most pronounced influence on heart rhythm in anesthetized rats; enalapril was less potent in this respect.

Population structure of hyperinvasive serotype 12F, clonal complex 218 Streptococcus pneumoniae revealed by multilocus boxB sequence typing.

At least four outbreaks of invasive disease caused by serotype 12F, clonal complex 218 Streptococcus pneumoniae have occurred in the United States over the past two decades. We studied the population structure of this clonal complex using a sample of 203 outbreak and surveillance isolates that were collected over 22 years from 34 US states and eight other countries. Conventional multilocus sequence typing identified five types and distinguished a single outbreak from the others.

[Actual problems of organization of medical provision for military hospitals in now-day's condition and the way of there solution].

Affording of qualified and specialized medical attendance in military hospitals is possible only in condition of presence of medical techniques and medical equipment in indispensable quantity. The units of medical supply have as a task to provide military hospitals by medical equipment. Nowadays the task of reoutfit of military hospitals by new medical equipment is one of the most significant for the medical service of Armed Forces.

[Evaluation of the effectivenes of treatment of patients with renal arterial hypertension with carvedilol].

The aim of the study was to compare the hypotensive effect and safety of carvedilol, a non-selective alpha-beta blocker, and monopril, an angiotensin-converting enzyme inhibitor (ACEi), in patients with arterial hypertension and a chronic renal disease. The main group (MG), 26 patients, was treated with carvedilol, which was administered as a hypotensive agent instead of the ACEi. The control group (CG) included 24 patients on a "standard" therapy with hypothiazide 12.

[Characteristics of community-acquired pneumonia in servicemen during the military conflict on the Northern Caucasus in 1995-1996].

The data of the examination and treatment of 1150 sick servicemen in different conditions of service in Republic of Chechnya in the military conflict in 1995-1996 are investigated. It was found out that the principal somatic pathology in the structure of sanitary losses of servicemen in the military conflict was respiratory organ diseases, mainly pneumonia, whose etiology as a rule does not depend on the character of the military-and-professional activities and places of troops' distribution. The chief role in the etiology of pneumonia was played by Streptococcus pneumoniae (43.