Cytotoxicity and Antitumor Activity of Arglabin and its Derivatives.

Background: At present, more than 8000 sesquiterpene lactones have been isolated and described from natural sources, a significant part of which has cytotoxicity and antitumor activity. One of the practically available sesquiterpene lactones is arglabin, which, as a renewable material, is used for the synthesis of new compounds. The article presents data on the study of cytotoxicity and antitumor activity of the arglabin and its derivatives using molecular modeling methods and, in the experiment and .

An Estimation of the Antiviral Activity and Toxicity of Biologically Active Substances Obtained from the Raw Materials of Berg. In Vitro and In Vivo.

Species of the genus Artemisia are well known for their use as ingredients in ancient medicine. The advantage of using plant extracts compared to individual pharmaceutical ingredients is the rate of adaptation of the pathogenic microorganisms to the drug. Due to the rapid development of multidrug-resistance in microorganisms in the field, it is essential to search for novel, effective drugs with low toxicity.

Study of Component Composition and Antimicrobial Activity of the Ophthalmic Emulsion Based on the Safflower Flowers ().

The use of medicinal plants has increased significantly in recent years. More than 80% of the world's population uses medicinal plants to treat themselves. Many antibacterial and anti-inflammatory synthetic drugs are available in medical practice.

Chemical Composition and Antimicrobial Activity of Subcritical CO Extract of L. (Brassicaceae).

The genus L. from Brassicaceae Burnett. family covers over 150 species with an almost cosmopolitan spread.

Neoadjuvant Therapy with Drug Arglabin for Breast Cancer with Expression of H-Ras Oncoproteins.

Backgrounds: In breast cancer, blocking of Ras signaling and inhibition of H-Ras is quite promising. H-Ras may become a target for farnesyl transferase inhibitors, and in combination with other immunohistochemical factors it will contribute to the progression of a breast tumor.

Purpose: The aim of this study was to evaluate the effectiveness of neoadjuvant therapy for breast cancer with the inclusion of farnesyl transferase inhibitor, arglabin interfering with the expression and concentration of H-Ras oncoproteins.

Non-pharmacological Treatment of Refractory Angina and Microvascular Angina.

Refractory angina (RA) is defined as debilitating anginal symptoms despite the optimal guideline-directed combination of medical, percutaneous, and surgical therapies. Often referred to as "no option", these patients represent a significant unmet clinical need for healthcare institutions. Due to the ageing of the population, and increased survival from coronary artery disease, the number of patients with RA is expected to rise exponentially.

Randomised, non-inferiority, controlled procedural outcomes TrIal comParing reverse T And Protrusion versus double-kissing and crush stenting: protocol of the TIP TAP I randomised trial.

Introduction: To assess the impact of 'reverse T and Protrusion' (TAP) technique on the outcome after stenting of true bifurcation lesions of the left main (LM) or proximal epicardial vessels as compared with double kissing (DK)-crush technique.

Methods And Analysis: 50 consecutive patients with true coronary bifurcation lesion (Medina 1,1,1 or 0,1,1) of the LM or the proximal main vessels, requiring a two-stent technique as first-line strategy at University Medical Center Mainz, are randomised in a 1:1 ratio to reverse TAP or DK-crush stenting. As recommended by best clinical practice, final angiographic result is evaluated and optical coherence tomographic (OCT) intracoronary imaging is performed to assess and optimise the final result.

Experimental, Clinical and Morphological Analysis of H-Ras Oncoproteins for Locally Advanced Breast Cancer.

Background: Activated forms of Ras are enhanced in both breast cancer as well as the cell lines with EGFR and HER2 expression. Therefore, H-Ras could be activated in breast tumours in the absence of direct mutational activation of Ras itself and could contribute to 20-50% of the cases. Expression inhibition, signal transduction interruption from H-Ras to the nucleus could become a promising therapeutic target.

Risk Factors for and Seroprevalence of Tickborne Zoonotic Diseases among Livestock Owners, Kazakhstan.

Crimean-Congo hemorrhagic fever (CCHF), Q fever, and Lyme disease are endemic to southern Kazakhstan, but population-based serosurveys are lacking. We assessed risk factors and seroprevalence of these zoonoses and conducted surveys for CCHF-related knowledge, attitudes, and practices in the Zhambyl region of Kazakhstan. Weighted seroprevalence for CCHF among all participants was 1.

LONG-TERM RESULTS OF COMBINATION THERAPY FOR LOCALLY ADVANCED BREAST CANCER.

Breast cancer ranks first among the malignant tumors in women. In locally advanced breast cancer (LABC) treatment starts with neoadjuvant chemotherapy (CTx) with the standard regimens CMF, FAC, АС. A cytostatic drug, Arglabin, isolated and produced from Artemisia glabella Kar.

Wavepacket scattering of Dirac and Schrödinger particles on potential and magnetic barriers.

We investigate the dynamics of a charged particle moving in a graphene layer and in a two-dimensional electron gas, where it obeys the Dirac and the Schrödinger equations, respectively. The charge carriers are described as Gaussian wavepackets. The dynamics of the wavepackets is studied numerically by solving both quantum-mechanical and relativistic equations of motion.

[Mother thyroid status and development of enzymes of initial and final phases of carbohydrate hydrolysis].

The daily treatment of a lactating mother with thyroxine 50 micrograms/100 g b.w. from the first to 21st day of lactation resulted in an increase of the thyroxine level in serum and earlier induction of alpha-glycosidases (pancreatic alpha-amylase and enteral maltase, saccharase) and in the earlier repression of beta-galactosidases (intestinal lactase) in rats.

Delay in natural decline of lactase activity in the small intestine of prematurely weaned rats as related to changes in their thyroid status.

Premature weaning of suckling rats on the 15th day of life delayed the natural reduction of lactase activity in the small intestine and reduced the level of T4 in serum. Preliminary treatments (from day 12 to 14 of life) with exogenous T4 (1 mg/kg BW) or exposure to cold (10 degrees C) significantly increased the level of T4 in serum on the 15th day of life, and sharply accelerated the reduction of lactase activity. It is concluded that the delay in lactase reduction in prematurely weaned rats may be related to a decrease in serum thyroxine level.

[The effect of insufficient nutrition during the suckling of rats on their growth and digestion].

The average weight of the bodies and the small intestine brush was 30% less in the malnourished 21-day old rats as compared with the control. The weight of the pancreas was 18% less. A decrease in the hydrolytic strength of the enzyme pools followed the changes in enzymatic activity during the primary and the last hydrolysis of food.

[The physiological mechanisms of the delay in the functional maturation of the small intestine in rat pups prematurely switched from milk to definitive nutrition].

Weaving of 15-day rats delays the natural suppression of the small intestine lactase, induces sucrase activity and decreases the thyroxine level in the blood serum. Administration of thyroxine normalizes the level of this hormone in the blood serum as well the beginning of suppression of the lactase activity.

[The effect of heat exposure on the circadian rhythm of the enzymatic activity in different sections of the rat small intestine].

Two-hour heat exposure (40-41 degrees C) was shown to change the circadian rhythms of enteral gamma-amylase, maltase and sucrase activities. The character and obviousness of the changes depended on the type of enzyme activity and the portion of the small intestine. The heat exposure did not change daily mean levels of enzymatic activities and their distribution along the small intestine.

[Environmental factors and the functional development of the digestive system].

A single action of cold, heat and malnutrition prompts an early transition of the digestive-transport system from juvenile to adult type. Repeated actions of these factors decrease the hydrolytic-transporting function of the digestive tract, the decrease being age-dependent.

[The effect of protein-calorie food deficiency on the activity of enteral enzymes in growing rats].

30-day changes in enteral enzymes were followed up in test and control growing white rats. Test animals received protein- and calorie-deficient feeding. It was established that retardation of growth was more marked in protein than in calorie deficiency.

[The effect of stress on the enzyme systems of the enterocyte microvilli in rat pups and the possible mechanism of the transmission of stress effects from dam to progeny].

In suckling rats whose mothers had had an immobilisation stress or been injected HC and T4 at the last day of their pregnancy, the sucrase induction decreased in the small intestine, if the HC was injected on the 10th day of life. The hormone injection to 1-day suckling rats did not affect the induction. These effects seem to be exerted not by the direct permeation of hormone from mother to litter but to be mediated rather by a special factor "stressin".

[Changes in the saccharase and lactase activities of the small intestine in suckling rats prematurely weaned from the nursing dam].

In suckling rats prematurely weaned on the 15th, 17th, 19th or 21st day of life, the body weight and the weight of small intestine were studied as well as the activity of enteral sucrase and lactase. A delay in the gain of body weight and small intestine weight was the greater the earlier the sucklings had been weaned. The sucrase activity did not depend on the term of weaning.