Recent advancement of nanomedicine-based targeted delivery for cervical cancer treatment.

Cervical cancer is a huge worldwide health burden, impacting women in impoverished nations in particular. Traditional therapeutic approaches, such as surgery, radiation therapy, and chemotherapy, frequently result in systemic toxicity and ineffectiveness. Nanomedicine has emerged as a viable strategy for targeted delivery of therapeutic drugs to cancer cells while decreasing off-target effects and increasing treatment success in recent years.

Recent advances in the synthesis of new benzothiazole based anti-tubercular compounds.

This review highlights the recent synthetic developments of benzothiazole based anti-tubercular compounds and their and activity. The inhibitory concentrations of the newly synthesized molecules were compared with the standard reference drugs. The better inhibition potency was found in new benzothiazole derivatives against .

Impact of noncoding RNAs on cancer directed immune therapies: Now then and forever.

Accumulating evidence demonstrates that the host genome's epigenetic modifications are essential for living organisms to adapt to extreme conditions. DNA methylation, covalent modifications of histone and interassociation of noncoding RNAs facilitate the cellular manifestation of epigenetic changes in the genome. Out of various factors involved in the epigenetic programming of the host, noncoding RNAs (ncRNAs) such as microRNA (miRNA), long noncoding RNA (lncRNA), circular RNA, snoRNA and piRNA are new generation noncoding molecules that influence a variety of cellular processes like immunity, cellular differentiation and tumor development.

Phyto-complexation of galactomannan-stabilized calcium hydroxide and selenium-calcium hydroxide nanocomposite to enhance the seed-priming effect in Vigna radiata.

The evaluation of nano-priming effect with galactomannan stabilized Phyto-complexed calcium hydroxide (Ca(OH)), selenium oxyanion‑calcium hydroxide SeO-(Ca(OH)), and selenium‑calcium hydroxide Se-(Ca(OH)) nanocomposites was carried out in Vigna radiata (Green gram) seeds. The green source Cassia angustifolia seed rich in galactomannan and other phytoconstituents was detected experimentally and characterized with GC-MS, UV, FT-IR, NMR, XRD, and SEM studies. The highly active galactomannan and other biomolecules, enable their terminal oxygen and hydroxide groups to bind with calcium and selenium ions through bidentate and monodentate chelation, followed by bio-reduction.

Yin and yang of immunological memory in controlling infections: Overriding self defence mechanisms.

Immunological memory is critical for host immunity and decisive for individual to respond exponentially to previously encountered infection. Both T and B cell memory are known to orchestrate immunological memory with their central and effector memory arms contributing in prolonged immunity/defence mechanisms of host. While central memory helps in maintaining prolonged immunity for a particular infection, effector memory helps in keeping local/seasonal infection in control.

Evaluation of biopolymer-derived carbon dots as cancer diagnostic biomarkers for human monocyte cell lines (.

Fluorescent carbon dots were fabricated from () gum extract using direct microwave pyrolysis method. The are fine-tuned concerning three parameters, viz., NaOH addition (presence and absence), microwave power, and irradiation time.

Facile fabrication of green nano pure CeO and Mn-decorated CeO with Cassia angustifolia seed extract in water refinement by optimal photodegradation kinetics of malachite green.

To eradicate the aquatic pollution caused by dyes, trendily the global researchers provide dedication to dye degradation using nanostructured photocatalyst. This research work is dedicated to explore an advanced, facile, bio-compact green fabricated nanostructure for water refinement. In this regard, plant-mediated syntheses of pure CeO and Mn-decorated CeO nano-powders have been inspected using seed extract of Cassia angustifolia.

Investigating into the molecular interactions of flavonoids targeting NS2B-NS3 protease from ZIKA virus through approaches.

Zika virus (ZIKV), belongs to the flavivirus genus and Flaviviridae family that associated with serious diseased conditions like microcephaly and other neurological disorders (Guillan-Barré syndrome). As there is no vaccine or therapies available against ZIKV to date. Hence, it is an unmet need to find potential drug candidates and target sites against Zika virus infection.

Deciphering the dark proteome of Chikungunya virus.

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. The outbreak of CHIKV infection has been seen in many tropical and subtropical regions of the biosphere. Current reports evidenced that after outbreaks in 2005-06, the fitness of this virus propagating in Aedes albopictus enhanced due to the epistatic mutational changes in its envelope protein.