Personalised dosing of vancomycin: A prospective and retrospective comparative quasi-experimental study.

Aims: The 2019 update to the US consensus guideline for vancomycin therapeutic monitoring advocates using Bayesian-guided personalised dosing to maximise efficacy and minimise toxicity of vancomycin. We conducted an observational cohort study of the implementation of bed-side Bayesian-guided vancomycin dosing in vascular surgery patients.

Methods: Over a 9-month prospective study period, vascular surgery patients were dosed vancomycin using Bayesian-guided dosing decision tool (DoseMeRx) and compared retrospectively with a control group admitted to the same ward in the 14 months prior to the study and dosed using a standard algorithmic approach.

A Phase I study to determine the pharmacokinetic profile, safety and tolerability of sildenafil (Revatio ) in cardiac surgery: the REVAKI-1 study.

Aims: Acute kidney injury (AKI) is a common and severe complication of cardiac surgery. There is no effective prevention or treatment. Sildenafil citrate (Revatio , Pfizer Inc.

Analgesic techniques following thoracic surgery: a survey of United Kingdom practice.

Background And Objective: The authors present a national survey determining the current practice of postoperative analgesia after major thoracic surgery in the United Kingdom.

Methods: Two hundred and forty anaesthetists from 36 thoracic centres were surveyed and the response rate was 78%.

Results: The commonest analgesic technique after video-assisted thoracoscopic surgery is paravertebral block combined with patient-controlled analgesia with morphine.

Fencl-Stewart analysis of acid-base changes immediately after liver transplantation.

Objective: The Fencl-Stewart approach to acid-base physiology allows detailed, quantitative insights into acid-base disorders. We tested the hypothesis that this type of analysis would reveal complex acid-base changes in patients after liver transplantation that differed from those in a general intensive care unit population.

Methods: Data were collected retrospectively on patients on admission to the ICU after liver transplantation between 2001 and 2003 and prospectively on a convenience group of general ICU patients in 2001.