Publications by authors named "Rakesh S Motani"
Protein Eng Des Sel
May 2011
Article Synopsis
- Advances in protein crystallization methods, particularly for challenging membrane proteins, include a technique of co-crystallizing proteins with specific antibody fragments.
- Researchers developed new single-chain antibody fragments (scFv) that can bind to specific protein epitopes, modifying an existing scFv for enhanced expression and binding affinity.
- The study revealed that the newly engineered scFvs crystallize differently from the original, suggesting their potential as versatile chaperones for structure determination without relying on extensive antibody libraries.
