Sex differences in the neurochemical and functional effects of MDMA in Sprague-Dawley rats.

Rationale: 3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy") use has been associated with acute toxicities and persistent depletion of the neurotransmitter serotonin (5-HT).

Objectives: This study investigates whether sex differences in the acute and long-term effects of MDMA exist.

Methods: Male and female rats received saline or 15 mg/kg MDMA, ip, bid for 4 days.