Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in - Experimental Models.

(ashwagandha) has been used traditionally as a remedy for insomnia and to enhance cognitive function. The effects of ashwagandha extract (AE, 35% withanolide glycosides, Shoden) on the expression levels of γ-aminobutyric acid (GABA)ρ1 and histamine H3 receptors in glioblastoma (C6) cell lines were studied using semiquantitative reverse transcriptase-polymerase chain reactions. The effects of AE on sleep onset and duration were studied in Swiss albino mice using the pentobarbital-induced sleep model.

Reconstructive spectrometer using a photonic crystal cavity.

Optical spectrometers have propelled scientific and technological advancements in a wide range of fields. While sophisticated systems with excellent performance metrics are serving well in controlled laboratory environments, many applications require systems that are portable, economical, and robust to optical misalignment. Here, we propose and demonstrate a spectrometer that uses a planar one-dimensional photonic crystal cavity as a dispersive element and a reconstructive computational algorithm to extract spectral information from spatial patterns.

Tailoring Surface Self-Organization for Nanoscale Polygonal Morphology on Germanium.

The evolution of polygonal-shaped nanoholes on the (100) surface of germanium, aided by focused ion beam induced self-organization, is presented. The energetic beam of ions creates a viscous phase which, at a thermodynamical minimum, leads to surface self-organization. A directed viscous-flow along the predefined nanoholes provides well-ordered polygonal nanostructures, ranging from triangles to hexagons and octagons, as desired.

Controlled Manipulation and Multiscale Modeling of Suspended Silicon Nanostructures under Site-Specific Ion Irradiation.

In this work, controlled bidirectional deformation of suspended nanostructures by site-specific ion irradiation is presented. Multiscale modeling of the bidirectional deformation of nanostructures by site-specific ion irradiation is presented, incorporating molecular dynamics (MD) simulations together with finite element analysis, to substantiate the bending mechanism. Strain engineering of the free-standing nanostructure is employed for controlled deformation through site-specific kiloelectronvolt ion irradiation experimentally using a focused ion beam.

Weaving nanostructures with site-specific ion induced bidirectional bending.

Site-specific ion-irradiation is a promising tool fostering strain-engineering of freestanding nanostructures to realize 3D-configurations towards various functionalities. We first develop a novel approach of fabricating freestanding 3D silicon nanostructures by low dose ion-implantation followed by chemical-etching. The fabricated nanostructures can then be deformed bidirectionally by varying the local irradiation of kiloelectronvolt gallium ions.

Design and analysis of two-dimensional high-index-contrast grating surface-emitting lasers.

The use of a two-dimensional (2D) high-index-contrast grating (HCG) with square periodic lattice is proposed to realize surface-emitting lasers. This is possible because the use of 2D HCG, in which multiple resonant leaky modes are excited by the 2 orthogonal directions of the grating, causes the high reflective zone to be split into two regions. Hence, a dip of the reflectivity is formed to support the excitation of a resonant cavity-mode inside the 2D HCG.

Near-field focusing properties of zone plates in visible regime--new insights.

Near-field focusing properties of zone plates are investigated in the visible regime by a 3-dimensional finite-difference time-domain method. It is shown that Frensel zone plates (FZPs) with metallic coatings can achieve subwavelength focusing in the visible wavelength. The characteristics of subwavelength focusing are found to be independent of the type of metal coatings used.