Publications by authors named "Rakesh M P"
Anti-tumor drugs cause hand-foot syndrome through a variety of pathogenic mechanisms. Some chemotherapeutic medications that can cause HFS include 5FU, doxorubicin, capecitabine, high dose cytarabine, and others. These medications each have a unique mechanism resulting in HFS.
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- Tyrosine Kinase Inhibitors (TKIs) are drugs that disrupt protein kinases' signaling pathways, crucial for tumor cell growth and proliferation, and are commonly used to treat various cancers like colon, breast, kidney, and lung.
- These inhibitors can be utilized alone or alongside other targeted therapies for better treatment outcomes.
- However, TKIs may lead to proteinuria in some patients due to issues like dysfunction of the split diaphragm and acute tubular necrosis, which the paper reviews in terms of TKI action mechanisms, associated risks, and management strategies.