Objective: We tested the hypothesis that buprenorphine-clonidine-dexamethasone (BCD) extends perineural analgesia compared with plain bupivacaine (BPV) nerve blocks used for hip and knee replacement surgery.
Design: Prospective, parallel-arms, randomized, double-blind trial.
Setting: A single veterans' hospital.
Preoperative cardiac function is an important predictor of postoperative outcomes. Patients with heart failure are at higher risk of perioperative morbidity and mortality. Left ventricular ejection fraction, derived by standard echocardiography, is most frequently used to assess cardiac function in the intraoperative and postoperative periods.
View Article and Find Full Text PDFNeoplastic cells often reside in distinctive tumor hypoxia armed with a series of adaptive responses including oxidative stress, defective apoptotic machinery and neoangiogenesis, through that further confer cell survival improvement. Plants still acts as reservoir of natural chemicals to provide newer active pharmacophores. Scutellarein is flavones which has wide range of pharmacophoral effects.
View Article and Find Full Text PDFHypoxia is a feature of all solid tumours, contributing to tumour progression. Activation of HIF-1α plays a critical role in promoting tumour angiogenesis and metastasis. Since its expression is positively correlated with poor prognosis for cancer patients, HIF-1α is one of the most convincing anticancer targets.
View Article and Find Full Text PDFDuring the last wave of the interovulatory interval (IOI), the permutations of the relationship between the ovulatory follicle and the CL (ipsilateral vs. contralateral) and the number of follicular waves (two vs. three) per IOI differ in frequency of occurrence as follows: ipsilateral relationship and two waves (34%), contralateral relationship and two waves (34%), ipsilateral relationship and three waves (8%), and contralateral relationship and three waves (24%).
View Article and Find Full Text PDFThe hemodynamics of the developing CL and the future dominant follicle (DF) was studied in 22 heifers during wave 1 on Days 0 to 5 (Day 0 = ovulation). Color-Doppler ultrasonography was used to determine the resistance index (RI) at the most prominent Doppler signal in an ovarian arterial branch before entry into the ovary; a decrease in RI indicates a downstream increase in vascular perfusion. The RI for each of four intraovarian patterns averaged over days was different (P < 0.
View Article and Find Full Text PDFInterferon-τ (IFN-τ) has been recognized as the primary embryonic signal responsible for maternal recognition of pregnancy. Uterine endometrium produces both prostaglandin F2α (PGF2α ) and prostaglandin E2 (PGE2 ). PGF2α is responsible for the luteolysis; however, PGE2 favours establishment of pregnancy by its luteoprotective action.
View Article and Find Full Text PDFDiameter of follicles was determined every 12 hours and progesterone (P4), FSH, and LH concentrations were determined every 6 hours from Day 12 (Day 0 = ovulation) to the ovulation at the end of the interovulatory interval (IOI). Groups were assigned on the basis of an ipsilateral (Ipsi) versus contralateral (Contra) relationship between the preovulatory follicle and CL and two follicular waves (2W) versus three waves (3W) per IOI. Numbers of IOIs were Ipsi-2W (n = 6), Ipsi-3W (n = 6), and Contra-3W (n = 8).
View Article and Find Full Text PDFThe diameter of the dominant follicle (DF) of wave 1 was studied on Days 9 to 17 (Day 0 = ovulation) in a survey of the ipsilateral and contralateral relationships between the location of the DF and CL, and number of follicular waves per interovulatory interval (IOI). For contralateral relationships, regardless of number of waves the diameter of the DF of wave 1 decreased (P < 0.03) between Days 11 and 13 when referenced to the follicle-CL relationship of wave 1 and decreased (P < 0.
View Article and Find Full Text PDFBlood samples were collected and follicle diameters were determined daily beginning on Day 12 (Day 0 = ovulation) in 35 interovulatory intervals (IOIs) in heifers. A minor follicular wave with maximal diameter (6.0 ± 0.
View Article and Find Full Text PDFConcentrations of circulating hormones after Day 14 (Day 0 = ovulation) were determined daily in 87 interovulatory intervals (IOIs) in heifers. The IOIs were grouped into four permutations according to an ipsilateral (Ipsi) or contralateral (Contra) relationship between the CL and the preovulatory follicle and two (2W) or three (3W) follicular waves per IOI. The number of IOIs per group differed (P < 0.
View Article and Find Full Text PDFFollicular Wave 1 and 2 and the associated FSH Surge 1 and 2 were used to designate the first two waves and surges of the interovulatory interval in two experiments in heifers. In experiment 1, a group with early (group E, N = 9) and late (group L, N = 5) development of the dominant follicle of Wave 1 were used as natural models to study FSH/follicle coupling. The day of wave emergence and the day of deviation in diameters between the two largest follicles were not different between groups.
View Article and Find Full Text PDFJ Diabetes Sci Technol
November 2012
Background: Diabetes care is not presently available, accessible, or affordable to people living in rural areas in developing countries, such as India. The Chunampet Rural Diabetes Prevention Project (CRDPP) was conceived with the aim of implementing comprehensive diabetes screening, prevention, and treatment using a combination of telemedicine and personalized care in rural India.
Methods: This project was undertaken in a cluster of 42 villages in and around the Chunampet village in the state of Tamil Nadu in southern India.