Publications by authors named "Rajwinder Leha L"
Article Synopsis
- The PTEN gene, a tumor suppressor, is often inactivated in breast cancer, which may require additional genetic events for tumor formation despite germ-line mutations leading to nonmalignant growths.
- Most tumors from PTEN deletion in mice are well-differentiated and do not contain transplantable tumor-initiating cells, except for a rare poorly differentiated type that does.
- Poorly differentiated tumors show unique genetic features and reduced levels of microRNA-143/145; when this microRNA is knocked down, it increases tumor formation by activating RAS signaling, which is linked to worse outcomes in patients, especially in basal-like breast cancer cases.
