Mechanochemically synthesized mesoporous alumina: An advanced sorbent for post-processing concentration of I for cancer therapy.

High radioactive concentration of I in the form of I[NaI] solution is essential for preparation of large-dose therapeutic capsules used in the management of thyroid cancer. In this communication, we report the synthesis of mesoporous alumina sorbent (surface area = 292 ± 28 m/g, mean pore diameter = 6.8 ± 0.

Study of adsorption characteristics of Au(III) onto coal particles and their application as radiotracer in a coal gasifier.

This paper describes a systematic study carried out to investigate adsorption characteristics of Au onto the surface of coal particles using a radiotracer technique. The main objective of the study was to optimize labeling conditions and utilize the labeled coal particles as a radiotracer for tracing coal particles in fluidized bed coal gasifiers. The effect of various experimental factors such as pH, amount of adsorbent, initial gold concentration, temperature and contact time between adsorbate and adsorbent were studied to obtain optimum conditions for maximum adsorption of Au on coal particles from an aqueous solution.

Development of Semiautomated Module for Preparation of I Labeled Lipiodol for Liver Cancer Therapy.

Intra-arterial injection of I Lipiodol is an effective treatment option for primary hepatocellular carcinoma as it delivers high radiation dose to liver tumor tissue with minimal accumulation in adjacent normal tissue. The present article demonstrates design, fabrication, and utilization of a semiautomated radiosynthesis module for preparation of I labeled Lipiodol. The radiolabeling method was standardized for preparation of patient dose of I labeled Lipiodol radiochemical yield (RCY); radiochemical purity (RCP) and pharmaceutical purity of the product were determined using optimized procedures.

Preparation and preclinical evaluation of I-trastuzumab for breast cancer.

Trastuzumab that targets the human epidermal growth factor receptor type 2 (HER2) is known to benefit patients with HER2+ metastatic breast cancer. The objective was to explore the potential of I-trastuzumab for treatment of breast cancers. Radioiodination of trastuzumab was carried out by chloramine-T method, purified by using PD-10 column, and characterized by size exclusion high-performance liquid chromatography on a gel column.