Inevitable glutathione, then and now.

Glutathione a predominant tripeptide thiol compound of many prokaryotes and eukaryotes, is synthesized from its precursor amino acids eg. gamma-glutamate, cysteine and glycine. It is mainly involved in detoxication mechanisms through conjugation reactions.

Influence of antioxidants on metallothionein-mediated protection in cadmium-fed rats.

Reduced glutathione (GSH) and alpha-tocopherol offer significant protection against cadmium toxicity in rats. They mobilize cadmium from soft tissues like the liver and kidney, but not from the testis. They diminish oxidative stress by raising GSH and reducing lipid peroxidation.