Identification of plasma protein biomarkers for endometriosis and the development of statistical models for disease diagnosis.

Study Question: Can a panel of plasma protein biomarkers be identified to accurately and specifically diagnose endometriosis?

Summary Answer: A novel panel of 10 plasma protein biomarkers was identified and validated, demonstrating strong predictive accuracy for the diagnosis of endometriosis.

What Is Known Already: Endometriosis poses intricate medical challenges for affected individuals and their physicians, yet diagnosis currently takes an average of 7 years and normally requires invasive laparoscopy. Consequently, the need for a simple, accurate non-invasive diagnostic tool is paramount.

Fetal programming by the parental microbiome of offspring behavior, and DNA methylation and gene expression within the hippocampus.

Background: The microorganisms colonizing the gastrointestinal tract of animals, collectively referred to as the gut microbiome, affect numerous host behaviors dependent on the central nervous system (CNS). Studies comparing germ-free mice to normally colonized mice have demonstrated influences of the microbiome on anxiety-related behaviors, voluntary activity, and gene expression in the CNS. Additionally, there is epidemiologic evidence supporting an intergenerational influence of the maternal microbiome on neurodevelopment of offspring and behavior later in life.

Norovirus outbreaks due to contaminated drinking water and probable person-to-person transmission, Kerala, India, 2021.

Background: In July 2021, the Alappuzha district in Kerala, India, reported an unexpected number of acute gastroenteritis (772) cases (Outbreak A). On October 10, 2021, a university in Wayanad, Kerala, reported 25 acute gastroenteritis cases (Outbreak B). We described both the outbreaks and determined the agent, source and risk factors.

Problematic Internet Use Among Adolescent School Attendees: A School-based Study from Tamil Nadu, India.

Objective: To investigate the prevalence of problematic internet use (PIU) among adolescents and determine the associated factors contributing to PIU.

Methods: In April/May 2023, a cross-sectional study was conducted among adolescents studying in grades 9 to 12 in government and private non-residential schools in Western Tamil Nadu, India. Participants completed a semi-structured questionnaire assessing demographic characteristics, behavioral patterns, and internet usage.

Variations and National Perspectives on Evaluation and Management of Ventilator-Associated Pneumonia in Neonatal Intensive Care Units: An In-Depth Survey Analysis.

Introduction Infants in the neonatal intensive care unit (NICU) are vulnerable to ventilator-associated pneumonia (VAP), which increases their morbidity and mortality. There is a significant overlap of clinical features of neonatal VAP with other pulmonary pathologies, particularly in preterm infants, which can make the definitive diagnosis and management of VAP challenging. Objective Our study surveyed NICU providers across the United States to understand the perspectives and variations in neonatal VAP diagnostic and management practices.

Oxygen Scarcity and COVID-19: Lessons Learned During the May-June 2021 Peak, Karnataka, India.

Oxygen is a most essential medical gas. This report shows the observations during the second wave of oxygen management in Karnataka, India, where there was an unprecedented rise in COVID-19 cases during May-June 2021. The state was allocated 731 metric tons against the actual requirement 1200 (63%).

Optical Readout of Single-Molecule Magnets Magnetic Memories with Unpolarized Light.

Magnetic materials are widely used for many technologies in energy, health, transportation, computation, and data storage. For the latter, the readout of the magnetic state of a medium is crucial. Optical readout based on the magneto-optical Faraday effect was commercialized but soon abandoned because of the need for a complex circular polarization-sensitive readout.

Harnessing rain hose technology for water-saving sustainable irrigation and enhancing blackgram productivity in garden land.

Blackgram, a protein-rich pulse crop (24%), is crucial for combating food insecurity, particularly in malnourished and economically weak countries. Enhancing blackgram production requires improved, input-saving management practices. Given the challenges of climate change and population growth, efficient water management is vital for increasing pulse productivity and water use efficiency with minimal investment.

Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells.

Objectives: Mutations in Tissue Inhibitor of Metalloproteinases 3 (TIMP3) cause Sorsby's Fundus Dystrophy (SFD), a dominantly inherited, rare form of macular degeneration that results in vision loss. TIMP3 is synthesized primarily by retinal pigment epithelial (RPE) cells, which constitute the outer blood-retinal barrier. One major function of RPE is the synthesis and transport of vital nutrients, such as glucose, to the retina.

Targeting AKR1B10 by Drug Repurposing with Epalrestat Overcomes Chemoresistance in Non-Small Cell Lung Cancer Patient-Derived Tumor Organoids.

Purpose: Systemic treatments given to patients with non-small cell lung cancer (NSCLC) are often ineffective due to drug resistance. In the present study, we investigated patient-derived tumor organoids (PDTO) and matched tumor tissues from surgically treated patients with NSCLC to identify drug repurposing targets to overcome resistance toward standard-of-care platinum-based doublet chemotherapy.

Experimental Design: PDTOs were established from 10 prospectively enrolled patients with non-metastatic NSCLC from resected tumors.

Comparative Evaluation of the Accuracy of Dynamic Navigation and Free Hand Methods During Zygomatic Implant Placement: A Randomized Controlled Trial.

To assess and compare the precision and predictability of zygomatic implants in atrophic maxilla using conventional and dynamic navigation methods. This study was a randomized controlled clinical trial conducted in patients requiring zygomatic implant placements in the atrophic maxilla. Forty zygomatic implants were placed in systemically healthy individuals.

Filtering Eye-Tracking Data From an EyeLink 1000: Comparing Heuristic, Savitzky-Golay, IIR and FIR Digital Filters.

In a prior report (Raju et al., 2023) we concluded that, if the goal was to preserve events such as saccades, microsaccades, and smooth pursuit in eye-tracking recordings, data with sine wave frequencies less than 75 Hz were the signal and data above 75 Hz were noise. Here, we compare five filters in their ability to preserve signal and remove noise.

Determining Which Sine Wave Frequencies Correspond to Signal and Which Correspond to Noise in Eye-Tracking Time-Series.

The Fourier theorem states that any time-series can be decomposed into a set of sinusoidal frequencies, each with its own phase and amplitude. The literature suggests that some frequencies are important to reproduce key qualities of eye-movements ("signal") and some of frequencies are not important ("noise"). To investigate what is signal and what is noise, we analyzed our dataset in three ways: (1) visual inspection of plots of saccade, microsaccade and smooth pursuit exemplars; (2) analysis of the percentage of variance accounted for (PVAF) in 1,033 unfiltered saccade trajectories by each frequency band; (3) analyzing the main sequence relationship between saccade peak velocity and amplitude, based on a power law fit.

Vaccination with a Protective Ipa Protein-Containing Nanoemulsion Differentially Alters the Transcriptomic Profiles of Young and Elderly Mice following Infection.

spp. are responsible for bacillary dysentery or shigellosis transmitted via the fecal-oral route, causing significant morbidity and mortality, especially among vulnerable populations. There are currently no licensed vaccines.

Cooling Under a Blanketrol System Versus Cooling With an Arctic Sun Thermoregulation System (CATS) for Neonates Undergoing Therapeutic Hypothermia.

Background Despite evidence suggesting improved outcomes in neonates with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH), data on the impact of temperature variability during cooling and its association with clinical outcomes remain limited. Objective To compare the efficacy and ease of use of two different cooling systems, the Arctic Sun (Medivance, Inc., Louisville, CO) vs.

An educational intervention for improving knowledge, attitude, and practice of dietary salt intake among individuals with hypertension in public sector secondary care facilities, Agra, India, 2021.

We conducted a pre-post intervention study to determine knowledge, attitude, and practice toward dietary salt intake before, immediately, and 1-month after nurse-led one-on-one counseling. We purposively selected three public health facilities in Agra, India, and enrolled all eligible hypertensive patients aged 18-60 under treatment for ≥6 months. Of the 153 patients at the 1-month follow-up, counseling improved knowledge (4% vs.

The Effect of Broccoli Glucoraphanin Supplementation on Ameliorating High-Fat-Diet-Induced Obesity through the Gut Microbiome and Metabolome Interface.

Scope: Obesity and its metabolic comorbidities pose a major global challenge for public health. Glucoraphanin (GRN) is a natural bioactive compound enriched in broccoli that is known to have potential health benefits against various human chronic diseases.

Methods And Results: This study investigats the effects of broccoli GRN supplementation on body weight, metabolic parameters, gut microbiome and metabolome associated with obesity.

Supplemental phosphorus can be completely replaced with microbial phytase in White Leghorn layer diets.

1. A study was conducted to assess the possibility of totally replacing supplemental phosphorus sources in White Leghorn (WL) layer diets (aged 28 to 45 weeks of age) with microbial phytase supplementation. One thousand commercial layers (HyLine White) of 28 weeks of age were housed in California cages fitted in open-sided poultry shed at the rate of 20 layers in each replicate.

Face mask use in the city of Chennai, India: Results from three serial cross-sectional surveys, 2021.

Introduction: The Government of Tamil Nadu, India, mandated wearing face masks in public places to combat the COVID-19 pandemic. We established face mask surveillance and estimated the prevalence of appropriate mask use (covering the nose, mouth, and chin) in the slums and non-slums of Chennai at different time points in 2021.

Methods: We conducted three serial cross-sectional surveys in the outdoors and indoors of Chennai in March, July, and October 2021.

Pre-Medications for Non-Emergency Tracheal Intubation in the United States Neonatal Intensive Care Units.

Background: Premedication in neonates undergoing elective intubation effectively minimizes the negative physiological events of bradycardia, systemic hypertension, intracranial hypertension, and hypoxia. Premedication decreases procedure-related pain and discomfort. This study aimed to evaluate the current practice of pre-intubation medications for non-emergent intubations in preterm and term neonates in the United States.

Three-year black carbon aerosol synthesis over a pristine location surrounded by hillocks in Haryana state, India.

The three-year Black Carbon (BC) aerosol measurements made during 2020, 2021, and 2022 over a rural location, namely, Panchgaon, surrounded by Aravali hillocks (elevation of about 400-600 m) have been analyzed with an aim to determine their optical and radiative characteristics, seasonal and long-term variations in mass concentration. The affinity between these parameters and associated pollutants and planetary boundary layer height (PBLH), affected by the orography, to delineate their role in mass concentration changes with time have been investigated. The coincident OPAC (Optical Properties of Aerosols and Clouds) Model-derived aerosol optical depth (AOD), and single scattering albedo (SSA) have been compared with the observed BC mass concentration, and also with synchronous satellite measurements.

The Perfect Storm: A Case of Rapid-Onset Obesity With Hypoventilation, Hypothalamic, Autonomic Dysregulation, Neuroendocrine Tumor (ROHHADNET) With Heart Failure, Narcolepsy, and a Rare Location of a Pelvic Neuroendocrine Tumor.

Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) syndrome is a rare disease of concurrent respiratory dysfunction and autonomic dysregulation with endocrine abnormalities. ROHHADNET includes ROHHAD plus coexisting neuroendocrine tumors (NETs). We describe an eight-year-old boy, who originally presented at four years of age with rapid weight gain and hyperhidrosis and who developed mild obstructive sleep apnea (OSA).

A Comprehensive Analysis of Phytochemical Composition, Acute Toxicity Assessment, and Antioxidant Potential of Ethanolic Extract of Carica Papaya Seeds.

Background: Carica papaya seeds are rich in phytochemicals with potential health benefits, warranting safety and antioxidant assessments. This study comprehensively examined the ethanolic extract of Carica papaya seeds (EECPS) to elucidate its phytochemical composition, acute toxicity profile, and antioxidant activity.

Methods: Phytochemical analysis of EECPS revealed the presence of various bioactive compounds, including flavonoids, tannins, phenols, alkaloids, proteins, glycosides, and saponins.