Advancement in the Nose-to-Brain Drug delivery of FDA-approved drugs for the better management of Depression and Psychiatric disorders.

The Prevalence of Depressive and Psychiatric disorders is increasing globally, and despite the availability of numerous FDA-approved drugs, treatment remains challenging. Many conventional antidepressants and antipsychotic formulations face issues such as low solubility, high first-pass metabolism, poor bioavailability, inadequate blood-brain barrier penetration, and systemic side effects. These challenges lead to reduced efficacy, slower onset of action, and decreased patient adherence to treatment.

Sorption of pharmaceuticals over microplastics' surfaces: interaction mechanisms and governing factors.

Microplastics are one of the emerging and ubiquitous environmental pollutants. Recent studies have proven their co-existence with pharmaceuticals in the environment wherein microplastics act as a potential vector for the transportation of pharmaceuticals. Both microplastics and pharmaceuticals are charged moieties enriched with diverse functional groups resulting in the possibility of multiple interactions.