Biocompatible Porous Scaffolds of Chitosan/Poly(EG--PG) Blends with Tailored Pore Size and Nontoxic to Stem Cells: Preparation by Controlled Evaporation from Aqueous Acetic Acid Solution.

The preparation of porous films (average size variation from 1 to 32 μm) of a 1:1 blend of chitosan with poly(EG--PG) by the controlled evaporation of water from a 2 wt % aqueous acetic acid solution is reported. Interestingly, the blend exhibited porosity that could be tailored from 1 to 32 μm with the temperature of preparation of the blend film. The powder X-ray diffraction, Fourier transform infrared, and differential scanning calorimetry analyses of the films suggested the formation of partially miscible blends.