Induction of pluripotency.

The molecular and phenotypic irreversibility of mammalian cell differentiation was a fundamental principle of developmental biology at least until the 1980s, despite numerous reports dating back to the 1950s of the induction of pluripotency in amphibian cells by nuclear transfer (NT). Landmark reports in the 1980s and 1990s in sheep progressively challenged this dogmatic assumption; firstly, embryonic development of reconstructed embryos comprising whole (donor) blastomeres fused to enucleated oocytes, and famously, the cloning of Dolly from a terminally differentiated cell. Thus, the intrinsic ability of oocyte-derived factors to reverse the differentiated phenotype was confirmed.

Nanog is an essential factor for induction of pluripotency in somatic cells from endangered felids.

Nanog has an important role in pluripotency induction in bovines and snow leopards. To examine whether it was required for wild felids globally, we examined the induction of pluripotency in felids from Asia (Bengal tiger, Panthera tigris), Africa (serval, Leptailurus serval), and the Americas (jaguar, Panthera onca). Dermal fibroblasts were transduced with genes encoding the human transcription factors OCT4, SOX2, KLF4, and cMYC with or without NANOG.

Highly efficient Cu(In,Ga)Se2 solar cells grown on flexible polymer films.

Solar cells based on polycrystalline Cu(In,Ga)Se(2) absorber layers have yielded the highest conversion efficiency among all thin-film technologies, and the use of flexible polymer films as substrates offers several advantages in lowering manufacturing costs. However, given that conversion efficiency is crucial for cost-competitiveness, it is necessary to develop devices on flexible substrates that perform as well as those obtained on rigid substrates. Such comparable performance has not previously been achieved, primarily because polymer films require much lower substrate temperatures during absorber deposition, generally resulting in much lower efficiencies.

Surface plasmon resonance based fiber optic sensor for the IR region using a conducting metal oxide film.

Theoretical modeling of a surface plasmon resonance (SPR) based fiber optic sensor with a conducting metal oxide [indium tin oxide (ITO)] as the SPR active material is proposed. The theoretical analysis reveals that the proposed sensing probe can be utilized for sensing in the IR region, where most of the gases show their absorption regime. Comparison of sensitivity predicts that an ITO-layer-coated SPR-based fiber optic sensor is about 60% more sensitive than a gold-coated fiber optic sensor.

Theoretical modeling of a localized surface plasmon resonance based intensity modulated fiber optic refractive index sensor.

A localized surface plasmon resonance based fiber optic sensor for refractive index sensing has been analyzed theoretically. The effects of size of the spherical metal nanoparticle as well as the light sources on the performance of the sensor have been studied rigorously. It is observed that a diffuse light source along with an intensity modulation method gives better performance in terms of sensing range.