Publications by authors named "Rajneesh P Uzgare"
Article Synopsis
- A new melphalan hemoperfusion filter (GEN 2) was tested in pigs to assess its effectiveness in filtering melphalan during a simulated medical procedure.
- The filter showed a high efficiency of 99.0% in removing melphalan and maintained a low pressure gradient of 20.9 mmHg, indicating good blood flow.
- Although some blood components like albumin and platelets decreased during the procedure, the changes are considered manageable in a clinical setting.
Background: The goal of this study was to determine whether liver, gastric, or colonic cancer may be suitable targets for chemosaturation therapy with percutaneous hepatic perfusion (CS-PHP) and to assess the feasibility of utilizing other cytotoxic agents besides melphalan in the CS-PHP system.
Materials And Methods: Forty human cell lines were screened against three cytotoxic chemotherapeutic agents. Specifically, the dose-dependent effect of melphalan, oxaliplatin, and paclitaxel on proliferation and apoptosis in each cell line was evaluated.