Publisher Correction: Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux.

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Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux.

Vesicoureteric reflux (VUR) is the commonest urological anomaly in children. Despite treatment improvements, associated renal lesions - congenital dysplasia, acquired scarring or both - are a common cause of childhood hypertension and renal failure. Primary VUR is familial, with transmission rate and sibling risk both approaching 50%, and appears highly genetically heterogeneous.

Do C1q or IgM nephropathies predict disease severity in children with minimal change nephrotic syndrome?

Background: It has been suggested that C1q and immunoglobulin M (IgM) nephropathy are variants of minimal change nephrotic syndrome (MCNS). Many researchers believe that these two conditions signify a worse prognosis for children with MCNS in comparison with immunofluorescence (IF)-negative MCNS. The aim of our study was to determine the prognostic significance of C1q nephropathy and IgM nephropathy in children with MCNS.

Long-term prospective evaluation of an inpatient voiding reeducation program for lower urinary tract conditions in children.

Purpose: Our aim was to evaluate the efficacy of our treatment program for children with lower urinary tract conditions, developed at the Department of Pediatric Nephrology of the University Children's Hospital in Ljubljana.

Methods: Sixty-four patients with lower urinary tract conditions were randomly allocated to two groups. Group A received treatment immediately, whereas patients of group B received no treatment for a period of 3 months-the amount of time it takes to complete our program.

Ultrasound detection of vesicoureteral reflux in children.

Purpose: We present different ultrasound techniques to detect vesicoureteral reflux in children with special emphasis on voiding urosonography.

Materials And Methods: Urinary tract infection is a common problem in children that may be related to vesicoureteral reflux. Currently there is no consensus on investigations in children after the first urinary tract infection.

Self-reported adherence behavior in adolescent hypertensive patients: the role of illness representations and personality.

Objective: This exploratory study examined the role that illness representations and personality play in the various adherence behaviors of adolescents diagnosed with essential hypertension.

Methods: The participants were 97 hypertensive adolescents. They completed self-report questionnaires pertaining to (1) demographic and medical data, (2) adherence, (3) illness representations, and (4) personality.

Catheter-free methods for vesicoureteric reflux detection: our experience and a critical appraisal of existing data.

In recent years, the exact role of vesicoureteric reflux (VUR) in general has become controversial, though in some groups of children the knowledge of the existence or non-existence of VUR is still a very important issue. The number of techniques available for the assessment of VUR is increasing, and a new classification taking into account their real characteristics (direct/indirect, catheter-using/catheter-free, radiation-giving/radiation-free) has been proposed. The purpose of the following review is to evaluate the currently available evidence supporting the use of various catheter-free methods for VUR detection.

Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux.

Primary vesicoureteric reflux accounts for approximately 10% of kidney failure requiring dialysis or transplantation, and sibling studies suggest a large genetic component. Here, we report a whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux and reflux nephropathy. We used linkage and family-based association approaches to analyze 320 white families (661 affected individuals, generally from families with two affected siblings) from two populations (United Kingdom and Slovenian).

Sensitivity of ultrasonography in detecting renal parenchymal defects: 6 years' follow-up.

While (99m)Tc-dimercaptosuccinic acid (DMSA) scanning is still considered the most accurate method for the assessment of renal parenchymal defects (RPDs), our study 6 years previously suggested that ultrasonography (US) could be a safe and efficient substitute for this purpose, provided that it is reliably performed and that renal function parameters are followed. By comparison of the original and follow-up study data from 67 children, the accuracy of our recommendations was re-evaluated. US was performed and renal function parameters investigated and correlated to the DMSA scans from the original study.

Ureteric jet Doppler waveform: is it a reliable predictor of vesicoureteric reflux in children?

The purpose of our prospective study was to find out whether ureteric jet Doppler waveform (UJDW) could be a reliable predictor of vesicoureteral reflux (VUR) in children, compared with echo-enhanced voiding ultrasonography (VUS). Echo-enhanced VUS was performed in 75 children, 57 girls and 18 boys, aged 3 years to 12 years, following the accepted indications for this procedure. During the same procedure the measurement of UJDW was also performed and was considered to be successful (in 70 children) when at least ten UJDWs were recorded per ureteric unit.

C1Q nephropathy in children.

C1q nephropathy (C1qNP) is a peculiar form of glomerulonephritis characterized by mesangial immunoglobulin and complement deposits, predominantly C1q, with no evidence of systemic lupus erythematosus. We describe the incidence, manifestation, histopathologic findings, follow-up, treatment and outcome of C1qNP. Twelve C1qNP patients were identified among 131 children who had undergone renal biopsy, accounting for a 9.

Effect of intermittent compression of upper arm veins on forearm vessels in patients with end-stage renal disease.

Native arteriovenous fistula is the best vascular access for chronic hemodialysis. Primary and long-term success depends, in part, on the state of arteries and veins at the time of the operation. The aim of our study was to investigate the effects of intermittent compression of upper arm veins on forearm vessels in patients with terminal renal disease.

Indirect voiding urosonography for detecting vesicoureteral reflux in children.

The purpose of our prospective study was to determine the value of indirect voiding urosonography without the use of contrast-media and without filling of the bladder through a catheter (IVUS) for detection of vesicoureteral reflux (VUR) in children, compared with echo-enhanced voiding urosonography (VUS). Among 57 children (45 girls and 12 boys, aged 2.7 to 12.

Effects of handgrip training and intermittent compression of upper arm veins on forearm vessels in patients with end-stage renal failure.

The purpose of our study was to assess the influence of handgrip training and intermittent compression of the upper arm veins on forearm arteries and veins. Eighteen chronic hemodialysis patients performed daily handgrip training for 8 weeks using a rubber ring, together with daily intermittent compression of the upper arm veins by elastic band. The forearm circumference, maximal handgrip strength, and arterial and vein parameters, including endothelium-dependent vasodilatation, were measured at the beginning, and after 4 and 8 weeks (using ultrasound scanning).

Effect of local physical training on the forearm arteries and veins in patients with end-stage renal disease.

Aim: We investigate the effects of local training on the forearm vessels in patients with end-stage renal disease.

Methods: Fourteen hemodialysis patients were included. Handgrip training was performed for 8 weeks.

Cyclic voiding urosonography in detecting vesicoureteral reflux in children.

Three methods are currently used to identify vesicoureteral reflux (VUR) in children, namely X-ray voiding cystourethrography (VCUG), radionuclide voiding cystography (RVC), and, recently, echo-enhanced voiding urosonography (VUS). It is known that the sensitivity of VCUG and RVC for detecting VUR can be improved by using cyclic procedures, such as repeated bladder filling and voiding. The purpose of our prospective study was to evaluate whether the cyclic procedure is superior to the conventional (one cycle only) procedure in VUS also.

Erythrocyte deformability and microhematuria in children and adolescents.

The aim of this study was to investigate whether erythrocyte deformability is higher in otherwise healthy children and adolescents with asymptomatic isolated glomerular microhematuria and no clinical or laboratory signs indicating renal disorder. Erythrocyte deformability in 33 children and adolescents with unexplained asymptomatic isolated glomerular microhematuria (study group) was compared with erythrocyte deformability in 133 individuals without urinary tract disease and without microhematuria (control group), 26 patients with microhematuria and IgA nephropathy (IgA nephropathy group), and 31 children and adolescents with benign familial hematuria (benign familial hematuria group). The erythrocyte and buffer filtration time was measured, the erythrocyte-to-buffer filtration time ratio calculated, and, on the basis thereof, erythrocyte deformability was estimated as an inverse proportion of the erythrocyte-to-buffer filtration time ratio in all subjects.

Sensitivity of ultrasonography in detecting renal parenchymal defects in children.

Renal parenchymal defects (RPD) -- scars, hypoplasia/dysplasia -- in children are a major risk factor for chronic renal failure. Most authors would agree that RPD should be detected and followed by a 99mTc-dimercaptosuccinic acid renal scan (DMSA), as ultrasonography (US) does not seem to be sensitive enough for this purpose. However, it might well be that DMSA is too sensitive and detects RPD that are too small to be clinically significant.