Ferrocenyl Azoles: Versatile N-Containing Heterocycles and their Anticancer Activities.

The medicinal chemistry of ferrocene has gained its momentum after the discovery of biological activities of ferrocifen and ferroquine. These ferrocenyl drugs have been designed by replacing the aromatic moiety of the organic drugs, tamoxifen and chloroquine respectively, with a ferrocenyl unit. The promising biological activities of these ferrocenyl drugs have paved a path to explore the medicinal applications of several ferrocenyl conjugates.

π-Conjugated Materials Derived From Boron-Chalcogenophene Combination. A Brief Description of Synthetic Routes and Optoelectronic Applications.

Functional materials composed of Boron-chalcogenophene conjugates have emerged as promising ensemble featuring commendable optoelectronic properties. This review describes the categories, synthetic routes and optoelectronic applications of a range of boron-chalcogenophene conjugates. Conjugation and linking of different types of tri- and tetra-coordinated boron moieties with chalcogenophenes have remained an important strategy for constructing a range of functional materials.

Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose.

A series of twenty one Schiff bases based on boronate ester of 1,2-O-isopropylidene-α-d-xylofuranose scaffold were designed and synthesized by condensation of formyl or amino phenyl boronate esters with substituted anilines or 2-hydroxybenzaldehydes, respectively. All the imines are remarkably stable crystalline solids and were obtained in good yields. All the products were fully characterized by FT-IR, multinuclear NMR ((1)H, (13)C and (11)B) spectroscopy, and elemental analysis.

Sugar-boronate ester scaffold tethered pyridyl-imine palladium(II) complexes: synthesis and their in vitro anticancer evaluation.

A series of five palladium(ii) pyridyl-imine Schiff base complexes 5a-e containing boronate esters with protected sugar diols derived from d-xylose, l-sorbose and d-mannitol were designed and synthesized starting from pyridyl-imines generated in situ from 3-aminophenyl boronate ester of sugars 3a-e and 2-pyridinecarboxaldehyde, followed by the addition of Pd(cod)Cl2 in dichloromethane solvent. All the complexes are remarkably stable orange/yellow crystalline solids and were obtained in good yields. The complexes were fully characterized by FT-IR, multinuclear NMR ((1)H, (13)C and (11)B), UV-visible spectroscopy, and elemental analysis.

Synthesis, structure and photophysical properties of ferrocenyl or mixed sandwich cobaltocenyl ester linked meso-tetratolylporphyrin dyads.

We report here the design and synthesis of porphyrin-metallocene dyads consisting of a metallocene [either ferrocene or mixed sandwich η(5)-[C5H4(COOH)]Co(η(4)-C4Ph4) connected via an ester linkage at meso phenyl position of either free-base or zinc porphyrin. All these dyad systems were characterized by various spectroscopic and electrochemical methods. A dimeric form of this molecule was observed in the X-ray crystal structure of Zn-TTPCo.

Effect of amide-triazole linkers on the electrochemical and biological properties of ferrocene-carbohydrate conjugates.

Amide-triazole linker incorporated ferrocene-carbohydrate conjugates were prepared by adopting a regiospecific copper(II)-catalysed 1,3-cycloaddition of ferrocenoyl propargylamide and isopropylidene/acetyl protected carbohydrate azides. Hydrophilic ferrocene glycoside with an amide-triazole linker was synthesised by deacetylation of the hydroxyl groups. All the new compounds were characterised by UV-visible and electrochemical studies and they were found to be stable in organic solvents as well as in the buffer system under physiological conditions (pH = 7.

Efficient synthesis, structural characterization and anti-microbial activity of chiral aryl boronate esters of 1,2-O-isopropylidene-α-D-xylofuranose.

A simple and efficient synthetic approach toward a series of chiral aryl boronate esters, starting from D-xylose, as anti-microbial agents, is described herein. Minimum inhibitory concentration and zone of inhibition revealed that these derivatives exhibit potent anti-bacterial and anti-fungal properties. Herein, we report the first anti-microbial activity of this class of compounds.

Novel Approach to Mixed Group 15/16 Element Ligands-Formation of Unusual Trichalcogenophosphonato Ligands in Mixed Fe/Cr Clusters.

Trithiophosphonato and triselenophosphonato ligands containing mixed Fe/Cr clusters have been synthesized from the reaction of [Fe (CO) (μ -Y) ] (Y=S or Se) with [CpCr(CO) (η -P ] in the presence of trimethylamine oxide. This novel approach leads to new clusters containing the first examples of P(S)S and P(Se)Se ligands in complexed forms.