Publications by authors named "Rajiv Potluri"
Human satellitess(HSats) are pericentric, tandemly repeating satellite DNA sequences in the human genome. While silent in normal cells, a subset of HSat2 noncoding RNA is expressed and accumulates in the nucleus of cancer cells. We developed a FISH-based approach for identification of the distribution of three subfamilies of HSat2 (A1, A2, B) sequences on individual human chromosomes.
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- Hematopoietic stem cells are influenced by their surrounding niche of endothelial and mesenchymal stromal cells in bone marrow, which plays a crucial role in leukemia development.
- Researchers discovered that leukemic cells release a peptide called apelin, which causes changes in the niche cells that promote the progression of leukemia.
- Blocking apelin in leukemic zebrafish showed a reduction in disease symptoms, suggesting that targeting apelin could be a promising new treatment approach for leukemia.
Article Synopsis
- In the MAPK pathway, the V600E mutation in B-Raf kinase leads to constant activation, resulting in excessive activity of downstream kinases MEK and ERK, contributing to melanoma and other cancers.
- Research indicates that existing drugs often fail due to resistance and can paradoxically activate B-Raf; therefore, new drugs targeting allosteric sites are necessary.
- By studying a specific α-helix on B-Raf crucial for its interaction with MEK, the research identifies potential new drug targets to inhibit B-Raf's oncogenic effects in melanoma.