The ERG1A K Channel Is More Abundant in Muscle from Cancer Patients Than that from Healthy Humans.

Background: The potassium channel encoded by the (a) has been detected in the atrophying skeletal muscle of mice experiencing either muscle disuse or cancer cachexia and further evidenced to contribute to muscle deterioration by enhancing ubiquitin proteolysis; however, to our knowledge, ERG1A has not been reported in human skeletal muscle.

Methods And Results: Here, using immunohistochemistry, we detect ERG1A immunofluorescence in human skeletal muscle sarcolemma. Further, using single point brightness data, we report the detection of ERG1A immunofluorescence at low levels in the muscle sarcolemma of young adult humans and show that it trends toward greater levels (10.

Colorado tick fever virus induces apoptosis in human endothelial cells to facilitate viral replication.

Colorado tick fever virus (CTFV) belongs to the genus Coltivirus of the Reoviridae family, and it is the causative agent of Colorado tick fever. Symptoms of the infection are characterized by sudden biphasic fever, headache, and petechial rash, while severe forms of the disease can include meningoencephalitis, hemorrhagic fever, and death in children. However, the mechanisms underlying CTFV induced pathology and severe complications remain unknown.

The sprightly little sphaerodactyl: Systematics and biogeography of the Puerto Rican dwarf geckos Sphaerodactylus (Gekkota, Sphaerodactylidae).

Studies of the Caribbean herpetofauna (amphibians and reptiles) have made significant contributions to our knowledge of evolutionary patterns and processes. A prerequisite for these studies are accurate taxonomies and robust phylogenetic hypotheses. One notable Caribbean radiation lacking such data are dwarf geckos of the genus Sphaerodactylus.

Chemically Engineered Synthetic Lipid Vesicles for Sensing and Visualization of Protein-Bilayer Interactions.

From pathogen intrusion to immune response, the cell membrane plays an important role in signal transduction. Such signals are important for cellular proliferation and survival. However, measurement of these subtle signals through the lipid membrane scaffold is challenging.

Probing Liquid-Solid and Vapor-Liquid-Solid Interfaces of Hierarchical Surfaces Using High-Resolution Microscopy.

Liquid-solid (LS) and vapor-liquid-solid (VLS) interfaces are important for the fundamental understanding of how surface chemistry impacts industrial processes and applications. Superhydrophobic surfaces, from structural hierarchies, were fabricated by coating flat smooth surfaces with hollow glass microspheres. These surfaces are referred to as structural hierarchical-modified microsphere surfaces (SHiMMs).

Ground-State versus Excited-State Interchromophoric Interaction: Topology Dependent Excimer Contribution in Metal-Organic Framework Photophysics.

Metal-organic frameworks (MOFs) define emerging materials with unique optoelectronic properties that stem from the highly organized chromophoric linkers within their frameworks. The extent of ground- and excited-state interchromophoric interaction among the π-conjugated macrocyclic linkers was studied within three tetraphenyl-pyrene (1,3,6,8-tetrakis(p-benzoic acid)pyrene; HTBAPy)-based MOFs: ROD-7 (In(OH)TBAPy, frz), NU-901 (scu), and NU-1000 (csq) via steady-state and time-resolved spectroscopic techniques. These experimental data along with computational results indicate that the extent of the interchromophoric interaction, leading to a reduced optical band gap, varies across the series of MOFs and is a function of the relative orientation of the TBAPy linkers determined by their respective framework topology.

Topology-dependent emissive properties of zirconium-based porphyrin MOFs.

Highly ordered chromophoric linkers positioned within the metal-organic frameworks (MOFs) have the potential to mimic natural light-harvesting complexes. Herein we report topological control over the photophysical properties of MOFs via modular interchromophoric electronic coupling to manifest different steady-state singlet emission spectra and their corresponding fluorescence lifetimes.