Cu(I)-Catalyzed C(sp)-H Functionalization of Amino Acids with Benzimidate and Reactive Oxygen Species (ROS) To Synthesize Triazines and 2-Pyrrolidinones.

An easily accessible Cu(I)-catalyzed regioselective oxidative C-N/C-O cross-coupling organic transformation has been disclosed for the syntheses of variably functionalized triazines and N-benzoylpyrrolidin-2-ones through the involvement of C(sp)-H bond functionalization, which is unknown in the literature. This general synthetic method is extended for decarboxylative oxidation of amino acids to install carbonyl functionality. It facilitates the formation of 2-3 new bonds through the cross-coupling strategy involving benzimidates, amino acids, and in situ-generated reactive oxygen species (ROS) from the aerial O as the sole oxidant.

Assessment of Low-Cost and Higher-End Soil Moisture Sensors across Various Moisture Ranges and Soil Textures.

The accuracy and unit cost of sensors are important factors for a continuous soil moisture monitoring system. This study compares the accuracy of four soil moisture sensors differing in unit costs in coarse-, fine-, and medium-textured soils. The sensor outputs were recorded for the VWC, ranging from 0% to 50%.

Organic Base-Promoted C-N- and C-O-Coupled Domino Cyclization Strategy: Syntheses of Oxazine-6-ones and 4-Pyrimidinols.

Oxazine-6-one and 4-pyrimidinol are two important frameworks in pharmaceutical production. Herein, we disclosed a simple, efficient, inexpensive organic base-promoted and additive-stimulated protocol for the syntheses of variably functionalized oxazine-6-ones and 4-pyrimidinols employing acetonitrile solvent under conventional heating conditions using an oil bath through C-N and C-O coupled domino steps. This simple practicable productive protocol utilizes easily producible cheap precursors, namely, benzimidates or benzamidines, with differently substituted dicyano-olefins, and it comprises step economy, robustness, and moisture insensitive conditions affording high yield that avoids the use of transition-metal catalysts, multistep with multicomponent strategy, and harsh reaction conditions involving hazardous chemicals.

Cu-Catalyzed Radical Reaction of Benzimidates to Form Valuable 4,5-Dihydrooxazoles through Regioselective Aerobic Oxidative Cross-Coupling.

A straightforward Cu(I)-catalyzed oxidative cross-coupled organic transformation has been developed under mild conditions for the construction of functionalized 4,5-dihydrooxazoles through a four-bond-forming regiocontrolled C-C/C-N/C-O coupling strategy emerging benzimidates, paraformaldehyde, and 1,3-diketo analogues using eco-friendly O as the sole oxidant. The fundamental features of these designed approaches involve operational simplicity, selectivity, generality, and a broad substrate scope with high yields under the same reaction conditions.

Hybrid Heterocycles: Ag(I)-Catalyzed C-C/C-N/C-O Coupled Cascade Dual Cyclization to Valuable Indolo-4-indolones and Indolo-4-chromenes.

Herein, we report a highly efficient Ag(I)-catalyzed indolyzation with Friedel-Crafts alkylation through a cascade cyclization strategy for accessing valuable hybrid heterocycles for the first time. This general strategy consists of forming four C-C/C-N/C-O bonds toward dual annulation reactions of 2-alkynylanilines with methyl benzoate-2-carboxaldehydes and aromatic amines, as well as with salicylaldehydes and malononitrile. Variably substituted new indolo-4-phthalimidines and indolo-4-chromenes were synthesized with excellent yields (85-93%) under mild reaction conditions.

Catalytic I-moist DMSO-mediated synthesis of valuable α-amidohydroxyketones and unsymmetrical -bisamides from benzimidates.

We developed an efficient and straightforward I-catalyzed strategy for the synthesis of functionalized α-amidohydroxyketones and symmetrical and unsymmetrical bisamides using incipient benzimidate scaffolds as starting materials and moist-DMSO as a reagent and solvent. The developed method proceeds through chemoselective intermolecular N-C-bond formation of benzimidates and the α-C(sp)-H bond of acetophenone moieties. The key advantages of these design approaches include broad substrate scope and moderate yields.

Inhibitory role of a smart nano-trifattyglyceride of root in epithelial ovarian cancer, through attenuation of FSHR - c-Myc axis.

Background And Aim: Epithelial ovarian cancer has the deadliest prognosis amongst gynaecological cancers, warranting an unmet need for newer drug targets. Based on its anticancer as well as abortifacient potential, Lam. root was hypothesized to have some implications in follicle stimulating hormone receptor (FSHR) dependent cancers like epithelial ovarian cancer.

Kinetic study and optimization of total solids for anaerobic digestion of kitchen waste: Bangladesh perspective.

Kitchen waste from hotels and homes is one of the major problems for urban and rural environment and could be one of the best sources of renewable energy by producing biogas through anaerobic digestion. A research work was undertaken to assess the methane potential of kitchen waste at different total solids (TS) content. Kitchen wastes such as spoiled rice, brinjal, potato, papaya, tomato, fish and poultry parts etc.

Benzimidates as -Diamidation and Amidoindolyzation Cascade Synthons with a Hydrated Ni Catalyst.

We contributed a new benzimidate chemistry through moisture-insensitive Ni/Ni-Fe combo-catalysis for a simultaneous 2-3 bond-forming -diamidation and amidoindolyzation cascade reaction to construct symmetrical and unsymmetrical -(arylmethylene)amides and indolo(arylmethylene)amides, using emerging benzimidate synthons. The operational simplicity, mild nature, generality, and robustness of the strategy were validated through syntheses of a wide range of new molecules, labile sugar-based chiral compounds, and pharmaceuticals with high yields under the same reaction conditions.

Selective amidation by a photocatalyzed umpolung reaction.

A metal-catalyzed organic transformation merged with another organophotocatalyst has been developed under mild conditions for production of α-ketoamides. CuI-catalyzed highly selective and rapid COCH-amidation in the presence of electrophilic C[double bond, length as m-dash]O bonds, which is synchronized by an eosin Y (EY)-photocatalyst, furnishes a wide range of labile α-ketoamides, unsymmetrical oxalamides and chiral analogues on the treatment of 1,3-dicarbonyls with amines, PhIO and LED light at room temperature. The current strategy opens up a new avenue to making photocatalysis a common synthetic tool for large-scale production in academia and industry.