Exploration of magnetic zeolite thin film derived from coal fly ash an efficient sorbent: Application to water treatment.

Fly ash, produced during coal combustion for energy making, which is recognized as an industrial by-product, could lead to environmental health hazards. Subsequently, fly ash found that an exceptional adsorption performance for the removal of various toxic pollutants, the adsorption capacity of fly ash might be altered by introducing physical/chemical stimulation. Successfully converting fly ash into zeolites not only recovers their disposal difficulties but also transforms unwanted materials into merchandisable products for various industrial applications.

Assessment of implant stability with resonance frequency analysis and changes in the thickness of keratinized tissue and crestal bone level using cone-beam computed tomography in two-stage implants: A three-dimensional clinicoradiographic study.

Background: The present study aims to evaluate a three-dimensional (3D) changes in the crestal bone levels (buccally, lingually/palatally, mesially, and distally) and in the thickness of keratinized tissue around single or multiple implants using cone-beam computed tomography (CBCT) after 1 year.

Materials And Methods: Twenty-eight implants were placed in the posterior load-bearing areas in 10 patients. The crestal bone levels and the thickness of keratinized tissue surrounding the edentulous area were assessed preoperatively, immediately after implant placement, and 1 year after implant placement using CBCT (3D imaging technique with DICOM software (Carestream Health, Rochester, NY)).

Pleurotus ostreatus Copper Nanoparticles: In Vitro and In Silico Evaluation of the Antioxidant, Antibacterial, and Antidiabetic Activities.

The rapid growth of nanotechnology has opened new frontiers in biomedical applications, particularly through the use of metal nanoparticles. This study explores the green synthesis of copper nanoparticles (CuNPs) using an aqueous extract of Pleurotus ostreatus (PO-CuNPs) and their characterization through UV-visible spectroscopy, FTIR, SEM, and EDAX. The synthesized PO-CuNPs demonstrated exceptional antioxidant activity, evident in hydrogen peroxide scavenging and phosphomolybdenum assays.

Sonochemical synthesis of guar gum - Zirconium phosphate composite for efficient capture of uranium from water.

The increasing presence of uranium as a radionuclide contaminant in water is a threat to human health and the environment. Sonication-assisted crosslinking of guar gum, a biopolymer, is carried out with zirconium phosphate to form an adsorbent (GG@ZrP) for the removal of uranium from water. The surface characteristics, functionalities, and thermal stability of the composite were established using various analytical and spectral tools.

Neurovascular Hamartoma of Palate-A Rare Case Report.

Unlabelled: The oral hamartoma is a unique presentation of head and neck tumors with nonspecific etiology and atypical histopathological presentation. Oral hamartomas generally present as smooth, painless, pinkish masses, histologically comprising neural and vascular components intermingled in connective tissue stroma. The presence of a neurovascular hamartoma (NVH) within the oral cavity is truly a rare entity, scarcely reported in the literature.

3D-Printed Latticed Microneedle Array Patches for Tunable and Versatile Intradermal Delivery.

Using high-resolution 3D printing, a novel class of microneedle array patches (MAPs) is introduced, called latticed MAPs (L-MAPs). Unlike most MAPs which are composed of either solid structures or hollow needles, L-MAPs incorporate tapered struts that form hollow cells capable of trapping liquid droplets. The lattice structures can also be coated with traditional viscous coating formulations, enabling both liquid- and solid-state cargo delivery, on a single patch.

An assessment of narrative operative reports for Wilms tumor resection using consensus component criteria.

Introduction: Precision in surgical documentation is essential to avoid miscommunication and errors in patient care. Synoptic operative reports are more precise than narrative operative reports, however they have not been widely implemented in pediatric surgical oncology. To assess the need for implementation of synoptic operative reports in pediatric surgical oncology, we examined the completeness of narrative operative reports in patients undergoing resection of Wilms tumor.

Unraveling the Enigma: A Five-Year Comprehensive Analysis of Hurthle Cell Tumors in South India's Tertiary Care Center.

Background: Hurthle cell tumors of the thyroid gland constitute a rare and enigmatic group of neoplasms, characterized by the presence of Hurthle cells exhibiting abundant eosinophilic cytoplasm and numerous mitochondria. Despite their low incidence, they pose diagnostic challenges and display diverse clinical outcomes. This study aims to provide a comprehensive analysis of the clinicopathological profile of Hurthle cell tumors within a tertiary care center in South India.

Characterization of prolycopene-accumulated Tan mutant of .

Significant progress has been made in understanding carotenoid biosynthesis in tomato (), and most pathway genes have been cloned and characterized. However, isolation and characterization of novel fruit ripening mutants is a continuous and essential process. This study describes the characterization of the Tan (Tangerine) mutant of .

Green synthesis of copper-based nanoparticles: study and ADMET analysis to assess their antioxidant, antibacterial, and cytotoxic effects.

Nanobiotechnology is a popular branch of science that is gaining interest among scientists and researchers as it allows for the green manufacturing of nanoparticles by employing plants as reducing agents. This method is safe, cheap, reproducible, and eco-friendly. In this study, the therapeutic property of fruit was mixed with the antibacterial activity of metallic copper to produce copper nanoparticles.

Acute pancreatitis following endoscopic ampullary biopsy: A case report.

Background: Endoscopic biopsy is mandatory for the diagnosis of malignant and premalignant ampullary tumours. The commonly reported inadvertent complications following routine mucosal biopsy include perforation and haemorrhage. Acute pancreatitis is an extremely rare complication following this procedure.

Rathke Cleft Cyst with Occulomotor Palsy: An Unusual Presentation.

Rathke cleft cysts arise from remnants of Rathke's pouch. Often identified as incidental autopsy findings, these cysts can occasionally become large enough to cause headache, vision impairment, hypothalamic pituitary dysfunction and rarely, cranial neuropathy. MRI is the imaging modality of choice with surgical drainage recommended in symptomatic cases.

Diagnostic Utility of NLR, PLR and MLR in Early Diagnosis of Gastric Cancer: an Analytical Cross-Sectional Study.

Purpose: Inflammatory markers such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) are linked with the pathogenesis of gastric cancer (GC). However, the clinical significance of the combination of these markers is unclear. Hence, this study was carried out to determine the individual and combined diagnostic accuracy of NLR, PLR and MLR among patients with GC.

A cradle to cradle approach towards remediation of uranium from water using carbonized arecanut husk fiber.

Sustainable materials for remediation of pollutants from water is the need of the hour. In this study two carbonaceous adsorbents prepared through hydrothermal carbonisation and pyrolysis from arecanut husk fiber, an agricultural waste material were used for the adsorption of uranium from water. Batch adsorption data as interpreted using the Langmuir model showed adsorption capacities of 250 mg g and 200 mg g respectively at pH 6 for the hydrochar (AHFC) and the pyrochar (AHFT) exceeding that reported for most of the unmodified biochars.

3D-Printed Microarray Patches for Transdermal Applications.

The intradermal (ID) space has been actively explored as a means for drug delivery and diagnostics that is minimally invasive. Microneedles or microneedle patches or microarray patches (MAPs) are comprised of a series of micrometer-sized projections that can painlessly puncture the skin and access the epidermal/dermal layer. MAPs have failed to reach their full potential because many of these platforms rely on dated lithographic manufacturing processes or molding processes that are not easily scalable and hinder innovative designs of MAP geometries that can be achieved.

Exosome RNA Sequencing as a Tool in the Search for Cancer Biomarkers.

Numerous noninvasive methods are currently being used to determine biomarkers for diseases such as cancer. However, these methods are not always precise and reliable. Thus, there is an unmet need for better diagnostic and prognostic biomarkers that will be used to diagnose cancer in early, more treatable stages of the disease.

ETV6 Deficiency Unlocks ERG-Dependent Microsatellite Enhancers to Drive Aberrant Gene Activation in B-Lymphoblastic Leukemia.

Unlabelled: Distal enhancers play critical roles in sustaining oncogenic gene-expression programs. We identify aberrant enhancer-like activation of GGAA tandem repeats as a characteristic feature of B-cell acute lymphoblastic leukemia (B-ALL) with genetic defects of the ETV6 transcriptional repressor, including ETV6-RUNX1+ and ETV6-null B-ALL. We show that GGAA repeat enhancers are direct activators of previously identified ETV6-RUNX1+/- like B-ALL "signature" genes, including the likely leukemogenic driver EPOR.

Smoking and degenerative spinal disease: A systematic review.

Smoking is a major cause of morbidity and mortality worldwide and is responsible for the death of more than 8 million people per year globally. Through a systematic literature review, we aim to review the harmful effects of tobacco smoking on degenerative spinal diseases (DSD). DSD is a debilitating disease and there is a need to identify if smoking can be an attributable contender for the occurrence of this disease, as it can open up avenues for therapeutic options.

The Diagnostic Dilemma of Ruptured Liver Metastasis in a Patient with Lung Cancer: A case report.

Spontaneous rupture of a metastatic liver tumour is rarely documented in the literature when compared to hepatocellular carcinoma and other liver lesions, especially from a lung primary. We report a case of ruptured liver metastasis from an adenocarcinoma of the lung mimicking ruptured liver abscess, challenging the clinical diagnosis. A 42-year-female patient presented to a tertiary care institute in 2020 with complaints of abdominal pain, breathlessness and fever.

Novel benzoxazinone derivative as potent human neutrophil elastase inhibitor: Potential implications in lung injury.

Neutrophil elastase, a powerful physiological defence tool, may serve as drug target for diverse diseases due to its bystander effect on host cells like chronic obstructive pulmonary disease (COPD). Here, we synthesised seven novel benzoxazinone derivatives and identified that these synthetic compounds are human neutrophil elastase inhibitor that was demonstrated by enzyme substrate kinetic assay. One such compound, PD05, emerged as the most potent inhibitor with lower IC as compared to control drug sivelestat.

Analysis and Characterization of Lactobacillus paragasseri and Lacticaseibacillus paracasei: Two Probiotic Bacteria that Can Degrade Intestinal Oxalate in Hyperoxaluric Rats.

In the present study, we characterized the probiotic properties of two commercially available bacterial strains, Lactobacillus paragasseri UBLG-36 and Lacticaseibacillus paracasei UBLPC-87, and evaluated their ability to degrade oxalate in vitro and in a hyperoxaluria-induced nephrolithiasis rat model. UBLG-36 harboring two oxalate catabolizing genes, oxalyl coenzyme A decarboxylase (oxc) and formyl coenzyme A transferase (frc), was previously shown to degrade oxalate in vitro effectively. Here, we show that UBLPC-87, lacking both oxc and frc, could still degrade oxalate in vitro.

Development of oil-based gels as versatile drug delivery systems for pediatric applications.

Administering medicines to 0- to 5-year-old children in a resource-limited environment requires dosage forms that circumvent swallowing solids, avoid on-field reconstitution, and are thermostable, cheap, versatile, and taste masking. We present a strategy that stands to solve this multifaceted problem. As many drugs lack adequate water solubility, our formulations used oils, whose textures could be modified with gelling agents to form "oleogels.