Publications by authors named "Rajesh M Miranda"
Front Neural Circuits
May 2015
Article Synopsis
- Research indicates that spinal circuits can adapt through training and inflammation, similar to plasticity mechanisms in the hippocampus like long-term potentiation and NMDA receptors.
- Engaging spinal circuits can lead to metaplasticity, where controllable stimulation promotes adaptive plasticity and learning, while uncontrollable stimulation results in maladaptive plasticity that inhibits learning.
- The balance between adaptive and maladaptive plasticity is influenced by key neurochemicals such as brain derived neurotrophic factor (BDNF) and tumor necrosis factor (TNF), with BDNF playing a crucial role in restoring normal inhibitory functions in spinal circuits.
