Klotho protein: a new insight into the pathogenesis of essential hypertension.

Background: Essential hypertension is a most prevalent global health concern. Despite extensive research, the exact mechanisms contributing to essential hypertension remain unclear. Several factors contribute to the pathogenesis of essential hypertension.

Fok I and Bsm I gene polymorphism of vitamin D receptor and essential hypertension: a mechanistic link.

The vitamin D receptor (VDR) gene serves as a good candidate gene for susceptibility to essential hypertension. The gene regulates the renin angiotensin system by influencing blood pressure regulation. Around 3% of the human genome is regulated by the vitamin D endocrine system.