Metalloproteins structural and functional insights into immunological patterns.

Metalloproteins play a crucial role in regulating different aspects of the immune system in humans. They have various functions in immunity, including recognizing and presenting antigens, aiding in the movement and effectiveness of immune cells, and facilitating interactions between the host and pathogens. Understanding how these proteins work can help us develop new methods to control the immune response in different diseases.

Investigation on energy, economic, and environmental aspects of double-pass solar air heater.

Numerous research studies have found that a double-pass solar air heater (DPSAH) performs better than a single-pass solar air heater (SAH). This suggested study aims to evaluate the performance of a DPSAH setup in Southern Tamil Nadu, India. Several artificial roughness features have been incorporated into the solar black-coated absorber plate for this examination.

An effective solar assisted semi-cylindrical saline water desalination system with direct atomizer and energy storage materials for domestic use: an experimental investigation.

Solar still is the easiest method to purifying the saline water for domestic usage, but this method needs much improvement for better performance since it has lower productivity. In this paper, an experimental investigation is completed to analyse the semi cylindrical solar productivity still. The semi-cylindrical still is incorporated with direct atomizer and scrap used as an energy storage medium.

High-throughput virtual screening and molecular dynamics simulation reveals NPC170742 a novel chalconoid compound as a potential inhibitor of D-glycero-D-manno-heptose-1,7-bisphosphate 7-phosphatase in .

is a gram negative spiral shaped bacteria that causes peptic ulcer and gastric cancer. It Is the sixth most prevalent cancer in the world and the third leading cause of cancer death. The increase in reported cases of resistance to the drugs and antibiotics shows the need for the development of new and efficient drugs against the pathogen.

Circadian rhythms and cancer.

Circadian rhythms are autonomous oscillators developed by the molecular circadian clock, essential for coordinating internal time with the external environment in a 24-h daily cycle. In mammals, this circadian clock system plays a major role in all physiological processes and severely affects human health. The regulation of the circadian clock extends beyond the clock genes to involve several clock-controlled genes.

Combining molecular modelling and experimental approaches to gain mechanistic insights into the LuxP drug target in .

Autoinducer-2 can mediate inter- and intra-species communication signal between bacteria and these signals from AI-2 is noted from limited species of bacteria. In humans, is a pathogen that causes a wide range of illnesses and can survive in the host system and transmit infection. The process by which acquires the competence to live and disseminate infection remains unknown.

Effect of graphene nanopaint on performance of solar air heater attached with inclined and winglet baffles.

Solar air heater is widely used for drying and industrial processing application. Different artificial roughened surfaces and coatings over the absorber plates are used to improve their performance of solar air heater by increasing absorption and heat transfer. In this proposed work, the graphene-based nanopaint is prepared by wet chemical and ball milling method and the prepared graphene nanopaint is characterized using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD).

Enhancing the performance of a solar air heater by employing the broken V-shaped ribs.

This work aims to enhance the performance of a solar air heater (SAH) by introducing broken V-ribs as roughness elements on the absorber plate. The unit with a conventional flat absorber plate is referred to as the "FSAH," while the unit with a broken V-rib-shaped absorber plate is called the "VSAH." The experiment was performed for three air velocities: 25 m/s, 20 m/s, and 15 m/s and the corresponding air flow rates were 0.

SARS-CoV-2 ORF8 dimerization and binding mode analysis with class I MHC: computational approaches to identify COVID-19 inhibitors.

SARS-CoV-2 encodes eight accessory proteins, one of which, ORF8, has a poorly conserved sequence with SARS-CoV and its role in viral pathogenicity has recently been identified. ORF8 in SARS-CoV-2 has a unique functional feature that allows it to form a dimer structure linked by a disulfide bridge between Cys20 and Cys20 (S-S). This study provides structural characterization of natural mutant variants as well as the identification of potential drug candidates capable of binding directly to the interchain disulfide bridge.

Exploring the macromolecules for secretory pathway in cancer disease.

Secretory proteins play an important role in the tumor microenvironment and are widely distributed throughout tumor tissues. Tumor cells secrete a protein that mediates communication between tumor cells and stromal cells, thereby controlling tumor growth and affecting the success of cancer treatments in the clinic. The cancer secretome is produced by various secretory pathways and has a wide range of applications in oncoproteomics.

Environmental, economic, and performance assessment of solar air heater with inclined and winglet baffle.

To investigate the solar air heater's (SAH) effectiveness, experiments are conducted using flat plate and artificially roughened plate in terms of inclined and winglet baffles over the collector surface. This proposed system collector plate is made up of inclined and winglet ribs and serves as an artificial roughness generator. Air stream of 0.

In silico and In vitro Analysis of Nigella sativa Bioactives Against Chorismate Synthase of Listeria monocytogenes: a Target Protein for Biofilm Inhibition.

Listeria monocytogenes have the ability to form biofilms, which aid in the contamination of food and the evasion of antimicrobials. Consumption of L. monocytogenes laden food can promote mild to severe infection in humans and cause serious health issues.

Viral hijacking mechanism in humans through protein-protein interactions.

Numerous viruses have evolved mechanisms to inhibit or alter the host cell's apoptotic response as part of their coevolution with their hosts. The analysis of virus-host protein interactions require an in-depth understanding of both the viral and host protein structures and repertoires, as well as evolutionary mechanisms and pertinent biological facts. Throughout the course of a viral infection, there is constant battle for binding between virus and cellular proteins.

Immunological insights of selectins in human disease mechanism.

Selectin enzymes are glycoproteins and are an important adhesion molecule in the mammalian immune system, especially in the inflammatory response and the healing process of tissues. Selectins play an important role in a variety of biological processes, including the rolling of leukocytes in endothelial cells, a process known as the adhesion cascade. It has recently been discovered and reported that the selectin mechanism plays a role in cancer and thrombosis disease.

Exploring the biological behavior of Heat shock protein (HSPs) for understanding the Anti-ischemic stroke in humans.

Background: An ischemic stroke can be caused by thrombosis and ischemia, which is a major public health problem around the world, resulting in severe disability and a high death rate. The goal of this work is to examine and target various heat shock proteins (HSPs) via their interacting partners, which may have an anti-ischemic stroke impact.

Methods: Various heat shock proteins are identified and used for construction of PPI network through STRING webserver.

Therapeutic potential of nitric oxide synthase inhibitor from natural sources for the treatment of ischemic stroke.

Nitric oxide (NO) is one of the major signalling molecules in the mammalian body playing critical role in regulation of blood pressure, cardiovascular disease including stroke, immune activation, neuronal and cell communication. Moreover, hyper production of NO by the activity of nitric oxide synthase (NOS) involved in neuropathic pain, neurodegenerative disorders and stroke. Hence, the search on small molecules from the natural sources for the inhibition of NOS is desirable in therapeutic point of view.

Experimental study on the thermal performance of a solar air heater integrated with multi-geometry arrangements over the absorber plate.

A solar air heater (SAH) is investigated experimentally by employing multi-geometry arrangements over the absorber plate. In the current work, the absorber plate is designed with rectangular ribs, slits, and cylinders. For the proposed system, this multi-geometry arrangement serves as an artificial roughness (baffles).

HPV-mediated Cervical Cancer: A Systematic Review on Immunological Basis, Molecular Biology, and Immune Evasion Mechanisms.

Background: Human papillomavirus (HPV), one of the most frequently transmitted viruses, causes several malignancies, including cervical cancer.

Aim: Owing to its unique pathogenicity, the HPV virus can persist in the host organism for a longer duration than other viruses to complete its lifecycle. During its association with the host, HPV causes various pathological conditions affecting the immune system by evading the host's immune mechanisms, thereby leading to the progression of various diseases, including cancer.

Plasma levels of BAFF and APRIL are elevated in patients with asthma in Saudi Arabia.

B-cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) are members of the tumor necrosis factor superfamily of cytokines and can induce B cell activation, differentiation, and antibody production via interaction with their receptors, including transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI), B-cell maturation antigen (BCMA), and B-cell activating factor receptor (BAFF-R). Herein, we assessed the plasma protein levels of BAFF and APRIL in patients with asthma to determine whether their expression is correlated with total IgE production and examined the surface expression of BAFF/APRIL receptors on B cells. Blood samples were collected from 47 patients with controlled asthma symptoms and 20 healthy normal controls, and plasma levels of APRIL, BAFF, and total IgE protein were quantified by corresponding ELISA assays.

Interrogation of SrtA active site loop forming open/close lid conformations through extensive MD simulations for understanding binding selectivity of SrtA inhibitors.

is a gram positive, deadly spore forming bacteria causing anthrax and these bacteria having the complex mechanism in the cell wall envelope, which can adopt the changes in environmental conditions. In this, the membrane bound cell wall proteins are said to progressive drug target for the inhibition of . Among the cell wall proteins, the SrtA is one of the important mechanistic protein, which mediate the ligation with LPXTG motif by forming the amide bonds.

Assessment of airborne endotoxin in sandstorm dust and indoor environments using a novel passive sampling device in Al Zulfi city, Saudi Arabia - Establishing threshold exposure levels.

The impact of sandstorm dust events affects local air quality and public health. These issues are becoming of greater concern in Saudi Arabia. There is a significant lack of research on airborne endotoxin exposure and analysis in the Middle East countries and no coherent body of research exists focusing on sandstorm dust in worldwide.

Transcriptomics-Based Characterization of the Toxicity of ZnO Nanoparticles Against Chronic Myeloid Leukemia Cells.

Introduction: Zinc oxide nanoparticles (ZnO NPs) have recently attracted attention as potential anti-cancer agents. To the best of our knowledge, the toxicity of ZnO NPs against human chronic myeloid leukemia cells (K562 cell line) has not been studied using transcriptomics approach.

Objective: The goals of this study were to evaluate the capability of ZnO NPs to induce apoptosis in human chronic myeloid leukemia cells (K562 cells) and to investigate the putative mechanisms of action.

Cerebral Venous Thrombosis: A Comprehensive Review.

Background: Cerebral sinus venous thrombosis (CSVT) is a relatively rare, potentially fatal neurological condition that can be frequently overlooked due to the vague nature of its clinical and radiological presentation. A literature search on PubMed using the keyword "Cerebral sinus venous thrombosis" was performed. We searched for the epidemiology, risk factors, pathophysiology, clinical features, diagnosis, and treatment of CSVT.

Loss of ERAD bridging factor UBX2 modulates lipid metabolism and leads to ER stress-associated apoptosis during cadmium toxicity in Saccharomyces cerevisiae.

The endoplasmic reticulum (ER) stress potentially activates the unfolded protein response (UPR) and ER-associated protein degradation (ERAD) as quality-control mechanisms. During ERAD process, the ERAD adaptor protein Ubx2 serves as a bridging factor and transports the misfolded proteins from the ER to the cytosol for subsequent ubiquitylation and proteasomal degradation. Cadmium (Cd) is a toxic metal that initiates ER stress and has an impact on lipid homeostasis and this study focuses on the synergistic impact of Cd exposure and ERAD (using ubx2∆ strain).

Draft Genome of the Liver Fluke .

Fascioliasis, a neglected foodborne disease caused by liver flukes (genus ), affects more than 200 million people worldwide. Despite technological advances, little is known about the molecular biology and biochemistry of these flukes. We present the draft genome of for the first time.