Role of flavonoid troxerutin on blood pressure, oxidative stress and regulation of lipid metabolism.

The objective of the present study was to investigate the effects of troxerutin (TX) on N-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in male albino Wistar rats. L-NAME (40mg/kg body weight (bw)) administration caused a sustained increase in systolic blood pressure (SBP), levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), tissue lipids (liver and kidney) such as total cholesterol (TC), triglycerides (TG), free fatty acids (FFA), and significant decrease in the activities of enzymatic antioxidants, phospholipids (PL) and levels of non enzymatic antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E. To assess the toxicity if any of TX treatment, hepatic and renal function markers were measured.

Improving the detection of stage I pressure ulcers by enhancing digital color images.

It has been observed in previous studies that the detection of stage I pressure ulcers becomes more difficult by unaided visual inspection and/or by using currently available techniques with darker skin subjects, due to increased melanin content. This difficulty is indicated by the elevated proportion of black and hispanic patients developing more serious stage III and IV pressure ulcers compared to white patients. The ultimate goal of this project, undertaken by MARC at the University of Virginia, is to develop a low-cost, non-contact imaging-based stage I pressure ulcer detection system for use by support staff in assisted living and skilled nursing facilities to increase the ulcer detection rate over a wide range of skin colors.