Physiological Responses to Acute Heat Stress in Rohu, Labeo rohita: Insights from Liver Proteomics.

Heat stress is a major problem in aquaculture species, causing changes in physiology such as decreased feed intake, growth rate, reproduction, and internal cellular damage, thereby affecting fish's health. The effects of an acute heat stress simulating a daily rise and fall in temperature on summer days were evaluated in the liver proteome of rohu (Labeo rohita) fingerlings in the present study. The fish maintained at 30 °C were gradually exposed to a higher temperature of 36 °C at an increment rate of 1 °C per 1.

Lifestyle, Epstein-Barr virus infection, and other factors could impede nasopharyngeal cancer survivorship: a five-year cross-sectional study in North Eastern India.

Unlabelled: Nasopharyngeal Carcinoma (NPC) is one of the leading cancers in India's north-eastern (NE) region affecting a section of the population each year. A proportion of the NPC cases are observed to recur even after therapy, indicating the involvement of other factors. We aimed to explore the NPC and Epstein-Barr virus (EBV) burden in the NE region and investigate the prognostic factors for the NPC patients' poor survival and recurrence.

Assessment of Four Obturation Methods in Deciduous Teeth Using Digital Radiography: An Study.

Aim And Objective: This study was carried out to comparatively assess the efficiency of four methods of obturation viz Lentulo spiral, Navi tip syringe, Bi directional spiral, and Past inject carrier in deciduous teeth using vista scan.

Materials And Methods: A total sample of 100 primary root canals [4 groups of 25 canals each] with 2/3 of root length were selected and randomly allocated into four different obturating techniques, i.e.

Modified Conventional Root Canal Shaping Technique in Primary Teeth: An Study.

Aim And Objective: The purpose of the study was to compare the efficiency of modified conventional root canal shaping technique versus conventional shaping technique in primary teeth.

Materials And Methods: A total of 184 primary root canals (2 groups of 92 canals each) with two-thirds of root length were selected and randomly allocated into two different shaping techniques, i.e.

Altered proteome in translation initiation fidelity defective eIF5 mutant causes oxidative stress and DNA damage.

The recognition of the AUG start codon and selection of an open reading frame (ORF) is fundamental to protein biosynthesis. Defect in the fidelity of start codon selection adversely affect proteome and have a pleiotropic effect on cellular function. Using proteomic techniques, we identified differential protein abundance in the translation initiation fidelity defective eIF5 mutant that initiates translation using UUG codon in addition to the AUG start codon.

Delineation of altered brain proteins associated with furious rabies virus infection in dogs by quantitative proteomics.

Rabies is a fatal zoonotic disease caused by rabies virus (RABV). Despite the existence of control measures, dog-transmitted human rabies accounts for ˃95% reported cases due to unavailability of sensitive diagnostic methods, inadequate understanding of disease progression and absence of therapeutics. In addition, host factors and their role in RABV infection are poorly understood.

Evaluation of stress in three different fiber posts with two-dimensional finite element analysis.

Introduction: The primary function of corono-radicular post is to provide retention for the core and to reinforce and to replace the remaining coronal tooth structure. There is considerable controversy regarding optimal choice of the material. An ideal post system should exhibit fracture resistance higher than the average masticatory forces.

Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host factors having implication in the disease pathogenesis and severity.

Syrian golden hamsters (Mesocricetus auratus) infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manifests lung pathology. In this study, efforts were made to check the infectivity of a local SARS-CoV-2 isolate in a self-limiting and non-lethal hamster model and evaluate the differential expression of lung proteins during acute infection and convalescence. The findings of this study confirm the infectivity of this isolate in vivo.

Individuals Age Determination from Human Dental Pulp Through DNA Analysis by PCR.

 Age estimation in forensic odontology is having a great importance in recent times because of the request by court or other government authorities so that immigrants whose real age is unknown should not suffer unfair disadvantages because of their supposed age, and so that all legal procedures to which an individual's age is relevant can be properly followed.  The present study was planned to be conducted on pulp tissue and dental hard tissues derived from individuals for DNA isolation and age determination .  The present study was an experimental single-blinded study consisting of 30 extracted teeth categorized into three groups as follows: Group A: 10 to 20 years, Group B: 21 to 30 years, Group C: 31 to 40 years.

BAX -248 G>A and BCL2 -938 C>A Variant Lowers the Survival in Patients with Nasopharyngeal Carcinoma and Could be Associated with Tissue-Specific Malignancies: A Multi-Method Approach.

Background: The association of BAX -248 G>A and BCL2 -938 C>A with different cancers created conflicts.  We studied the correlation and the effect of these polymorphisms in patients with Nasopharyngeal Carcinoma (NPC).  Methods: PCR-RFLP and Sanger sequencing were used to detect polymorphisms.

Effect of Digitalized Previsit Imagery on Behavior of Children in the Dental Operatory.

Aim And Objective: The present study was aimed to determine the impact of exposure to digitalized previsit imagery technique on the anticipatory dental anxiety levels of children.

Design: 40 children, aged 4-8 years requiring noninvasive dental treatment were included in the study. Preintervention anxiety levels were assessed using Venham picture test (VPT) in the waiting room and randomly divided into two groups.

TLR9 Polymorphisms Might Contribute to the Ethnicity Bias for EBV-Infected Nasopharyngeal Carcinoma.

Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world, but is endemic in some ethnic groups. The association of NPC with the Epstein-Barr virus (EBV) is firmly established; however, the mechanism is still unclear. TLR9 is well known for its essential role in viral pathogen recognition and activation of innate immunity.

Histocompatibility locus antigens regions contribute to the ethnicity bias of Epstein-Barr virus-associated nasopharyngeal carcinoma in higher-incidence populations.

Nasopharyngeal carcinoma (NPC) is one the most confusing and rare malignancy in most part of the world with significantly high occurrence in some populations of Southeast Asia, North Africa and Alaska. Apart from the dietary and environmental factors, NPC is well-associated with Epstein-Barr virus (EBV) infection in these ethnic groups. However, the internal molecular mechanism(s) for such association in specific populations is not known till date.

Comparison of ocular wavefront aberrations in subluxated lenses before and after lens extraction with intraocular lens implantation.

Purpose: To compare the change in ocular higher-order wavefront aberrations (HOAs), visual acuity, and modulation transfer function (MTF) after lens extraction with intraocular lens (IOL) implantation in patients with subluxated lenses.

Setting: Iladevi Cataract & IOL Research Centre, Ahmedabad, India.

Design: Prospective case series.

Cone Beam Computed Tomography Evaluation of Hand Nickel-Titanium K-Files and Rotary System in Primary Teeth.

Purpose: The purpose of this study was to compare canal transportation, centering ability, and removed dentin thickness (RDT) using hand nickel-titanium (NiTi) K-flex files and rotary systems in primary molars and using cone beam computed tomography (CBCT).

Methods: This study was conducted on 20 primary maxillary and 20 primary mandibular molars, which were randomly divided into two groups to be instrumented with hand NiTi K-flex files and a rotary system. Pre- and post-instrumentation slices were taken at three predetermined levels using CBCT to evaluate all the parameters by using Digital Imaging Communications in Medicine (DICOM) software.

Assessment of caries status among schoolchildren according to decayed-missing-filled teeth/decayed-extract-filled teeth index, International Caries Detection and Assessment System, and Caries Assessment Spectrum and Treatment criteria.

Background: Detection and evaluation of dental caries is of epidemiological importance. Its early detection is important to commence appropriate treatment planning. Cavitated, noncavitated, and initial lesions of dental caries can be detected by various indices.

Erupted odontome associated with a primary molar: A unique clinical presentation, 4-year follow-up.

Erupted odontomas occur very rarely in both the primary and permanent dentitions. The present case report discusses an unusual erupted odontome associated with a primary first mandibular molar. A 7-year-old female patient with an erupted odontome in the oral cavity was reported.

A Study of Prescription Pattern of Neutraceuticals, Knowledge of the Patients and Cost in a Tertiary Care Hospital.

Introduction: Neutraceuticals are increasingly becoming a part of diet in a health-conscious society. People have changed their outlook towards neutraceuticals because of varying lifestyle diseases and they see the need to improve their physical and mental health.

Aim: To study the prescription pattern by doctors, knowledge of patients, cost for patients and patient satisfaction regarding neutraceuticals.

Clinical Evaluation of Conventional Radiography, Radiovisiography, and an Electronic Apex Locator in Determining the Working Length in Primary Teeth.

Purpose: This study's purposes were to: (1) compare the accuracy of conventional radiography (CR), radiovisiography (RVG), and the Root ZX mini apex locator (EAL) in determining the working length in primary teeth; and (2) determine the effect of wet/dry conditions on the accuracy of the EAL.

Methods: Twenty-two children (six to 15 years old), with 41 root canals of primary teeth with or without resorption indicated for extraction, were selected. CR and RVG were used to determine the working length, followed by EAL, according to the manufacturer's instructions in both dry and wet fields (saline).

Development of a Stability-Indicating Stereoselective Method for Quantification of the Enantiomer in the Drug Substance and Pharmaceutical Dosage Form of Rosuvastatin Calcium by an Enhanced Approach.

A novel, simple, precise, and stability-indicating stereoselective method was developed and validated for the accurate quantification of the enantiomer in the drug substance and pharmaceutical dosage forms of Rosuvastatin Calcium. The method is capable of quantifying the enantiomer in the presence of other related substances. The chromatographic separation was achieved with an immobilized cellulose stationary phase (Chiralpak IB) 250 mm x 4.

Evaluation of palatal rugae pattern in establishing identification and sex determination in Nalgonda children.

Background: Establishing individual identification of a decedent only by dental means is a mammoth task in forensic odontology. Palatal rugae's uniqueness, its resistance to heat, and stability throughout life have been proved by its use as an alternative aid in individual identification where comparison of fingerprints and other records is difficult.

Aims And Objectives: The aim of the present study was to analyze the role of palatal rugoscopy in personal identification and sex determination of Nalgonda pediatric population.

Evaluation of the Efficiency and Effectiveness of Three Minimally Invasive Methods of Caries Removal: An in vitro Study.

Background: Many chemomechanical caries removal (CMCR) agents have been introduced and marketed since 1970s, with each new one being better and effective than the previously introduced. Papacarie and Carisolv are new systems in the field of CMCR techniques. These are reportedly minimally invasive methods of removing carious dentin while preserving sound dentin.

Kaposi sarcoma herpes virus latency associated nuclear antigen protein release the G2/M cell cycle blocks by modulating ATM/ATR mediated checkpoint pathway.

The Kaposi's sarcoma-associated herpesvirus infects the human population and maintains latency stage of viral life cycle in a variety of cell types including cells of epithelial, mesenchymal and endothelial origin. The establishment of latent infection by KSHV requires the expression of an unique repertoire of genes among which latency associated nuclear antigen (LANA) plays a critical role in the replication of the viral genome. LANA regulates the transcription of a number of viral and cellular genes essential for the survival of the virus in the host cell.