A randomised-controlled trial (TARGET-C) of high vs. low target mean arterial pressure in patients with cirrhosis and septic shock.

Background & Aims: A high mean arterial pressure (MAP) target has been associated with improved renal outcomes in patients with cirrhosis, though it has not been studied in critically ill patients with cirrhosis and septic shock (CICs). We compared the efficacy of a high (80-85 mmHg; H-MAP) vs. low (60-65; L-MAP) target MAP strategy in improving 28-day mortality in CICs.

Incidence and Causes of Late Hospital Readmissions After Living Donor Renal Transplant: A Retrospective Study.

Objectives: Our primary aim was to find the incidence, causes, and factors responsible for late hospital readmissions.

Materials And Methods: There were 185 patients included in the study. The patients were divided into 2 groups: those with late readmission after discharge and those with no late readmission.

Standard-Volume Plasma Exchange Improves Outcomes in Patients With Acute Liver Failure: A Randomized Controlled Trial.

Background: High volume plasma-exchange (HVPE) improves survival in patients with acute liver failure (ALF), but apprehension regarding volume overload and worsening of cerebral edema remain.

Methods: In an open-label randomized controlled trial, 40 consecutive patients of ALF were randomized 1:1 to either standard medical treatment (SMT) or SMT with standard-volume plasma-exchange (SVPE). SVPE was performed using centrifugal apheresis [target volume of 1.

Development of predisposition, injury, response, organ failure model for predicting acute kidney injury in acute on chronic liver failure.

Background And Aim: There is limited data on predictors of acute kidney injury in acute on chronic liver failure. We developed a PIRO model (Predisposition, Injury, Response, Organ failure) for predicting acute kidney injury in a multicentric cohort of acute on chronic liver failure patients.

Patients And Methods: Data of 2360 patients from APASL-ACLF Research Consortium (AARC) was analysed.

Severe symptomatic hyponatremia--an uncommon presentation of tacrolimus nephrotoxicity.

Though tacrolimus-induced nephrotoxicity and hyperkalemia are well known, severe symptomatic hyponatremia is not commonly documented with its use. Here, we report a case of severe symptomatic hyponatremia in a renal transplant recipient on tacrolimus despite normal tacrolimus trough level. All other potential causes of hyponatremia were ruled out in this patient.