Publications by authors named "Rajendra Acharya"

Background: Data sharing in healthcare is vital for advancing research and personalized medicine. However, the process is hindered by privacy, ethical, and legal challenges associated with patient data. Synthetic data generation emerges as a promising solution, replicating statistical properties of real data while enhancing privacy protection.

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Generative Adversarial Networks (GANs) have emerged as a powerful tool in artificial intelligence, particularly for unsupervised learning. This systematic review analyzes GAN applications in healthcare, focusing on image and signal-based studies across various clinical domains. Following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, we reviewed 72 relevant journal articles.

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Sudden Cardiac Death (SCD) stands as a life-threatening cardiac event capable of swiftly claiming lives. Researchers have devised numerous models aimed at automatically predicting SCD through a combination of diverse feature extraction techniques and classifiers. We did a rigorous review of research publications ranging from 2011 to 2023, with a specific focus on the automated prediction of SCD, a growing health concern on a global scale.

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: Despite recent advances in research, cancer remains a significant public health concern and a leading cause of death. Among all cancer types, lung cancer is the most common cause of cancer-related deaths, with most cases linked to non-small cell lung cancer (NSCLC). Accurate classification of NSCLC subtypes is essential for developing treatment strategies.

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Article Synopsis
  • - This paper introduces a new framework for detecting Alzheimer's disease (AD) by analyzing EEG signals, utilizing a unique Lattice123 pattern inspired by the Shannon information entropy theorem for feature extraction.
  • - By generating directed graphs and using kernel functions, the model creates six feature vectors for each EEG signal, applying multilevel discrete wavelet transform (MDWT) to capture detailed features in both frequency and spatial domains.
  • - The model achieves over 98% classification accuracy and over 96% geometric mean, demonstrating its effectiveness in identifying subtle EEG signal changes related to AD, and is ready for validation with larger datasets.
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Electroencephalography (EEG) signals provide information about the brain activities, this study bridges neuroscience and machine learning by introducing an astronomy-inspired feature extraction model. In this work, we developed a novel feature extraction function, black-white hole pattern (BWHPat) which dynamically selects the most suitable pattern from 14 options. We developed BWHPat in a four-phase feature engineering model, involving multileveled feature extraction, feature selection, classification, and cortex map generation.

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Background And Objective: Sudden cardiac death (SCD) is a critical health issue characterized by the sudden failure of heart function, often caused by ventricular fibrillation (VF). Early prediction of SCD is crucial to enable timely interventions. However, current methods predict SCD only a few minutes before its onset, limiting intervention time.

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Cardiotocography (CTG) is used to assess the health of the fetus during birth or antenatally in the third trimester. It concurrently detects the maternal uterine contractions (UC) and fetal heart rate (FHR). Fetal distress, which may require therapeutic intervention, can be diagnosed using baseline FHR and its reaction to uterine contractions.

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Electroencephalogram (EEG) signals contain information about the brain's state as they reflect the brain's functioning. However, the manual interpretation of EEG signals is tedious and time-consuming. Therefore, automatic EEG translation models need to be proposed using machine learning methods.

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Sleep is an integral and vital component of human life, contributing significantly to overall health and well-being, but a considerable number of people worldwide experience sleep disorders. Sleep disorder diagnosis heavily depends on accurately classifying sleep stages. Traditionally, this classification has been performed manually by trained sleep technologists that visually inspect polysomnography records.

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Unlabelled: In this study, attention deficit hyperactivity disorder (ADHD), a childhood neurodevelopmental disorder, is being studied alongside its comorbidity, conduct disorder (CD), a behavioral disorder. Because ADHD and CD share commonalities, distinguishing them is difficult, thus increasing the risk of misdiagnosis. It is crucial that these two conditions are not mistakenly identified as the same because the treatment plan varies depending on whether the patient has CD or ADHD.

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Objectives: Breast cancer is a type of cancer caused by the uncontrolled growth of cells in the breast tissue. In a few cases, erroneous diagnosis of breast cancer by specialists and unnecessary biopsies can lead to various negative consequences. In some cases, radiologic examinations or clinical findings may raise the suspicion of breast cancer, but subsequent detailed evaluations may not confirm cancer.

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Article Synopsis
  • AI models can enhance patient management by utilizing digital health records, with machine-learning (ML) and deep-learning (DL) techniques improving clinical processes.
  • Medical imaging machines are becoming more intelligent through these models, aiding physicians in decision-making and increasing clinical efficiency.
  • This review provides an easy-to-understand guide for physicians on key evaluation metrics for AI models, highlights the development of four diagnostic models for breast cancer, and offers practical applications for interpreting model outputs.
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  • * A 2-year study tested 4 trap designs and 3 ethanol lures in Georgia and New York, focusing on major beetle species.
  • * Clear sticky cards were the most effective traps, especially when combined with specific low-release ethanol lures, enhancing capture rates of key pest species in both regions.
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Purpose: We applied machine learning to study associations between regional body fat distribution and diabetes mellitus in a population of community adults in order to investigate the predictive capability. We retrospectively analyzed a subset of data from the published Fasa cohort study using individual standard classifiers as well as ensemble learning algorithms.

Methods: We measured segmental body composition using the Tanita Analyzer BC-418 MA (Tanita Corp, Japan).

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Article Synopsis
  • Optical coherence tomography (OCT) provides high-resolution, non-invasive imaging that is crucial for diagnosing various eye diseases, including glaucoma and age-related macular degeneration, while also aiding in the detection of other conditions such as diabetic retinopathy and epiretinal membranes.
  • The systematic review followed the 2020 PRISMA guidelines, analyzing 1787 publications on eye conditions using machine learning (ML) and deep learning (DL), ultimately narrowing down to 76 relevant journal articles for in-depth study.
  • Challenges in using ML for decision support include managing numerous features and determining their relevance, whereas DL offers a more straightforward approach that doesn't require extensive trial and error.
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Fibromyalgia is a soft tissue rheumatism with significant qualitative and quantitative impact on sleep macro and micro architecture. The primary objective of this study is to analyze and identify automatically healthy individuals and those with fibromyalgia using sleep electroencephalography (EEG) signals. The study focused on the automatic detection and interpretation of EEG signals obtained from fibromyalgia patients.

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Myocarditis poses a significant health risk, often precipitated by viral infections like coronavirus disease, and can lead to fatal cardiac complications. As a less invasive alternative to the standard diagnostic practice of endomyocardial biopsy, which is highly invasive and thus limited to severe cases, cardiac magnetic resonance (CMR) imaging offers a promising solution for detecting myocardial abnormalities.This study introduces a deep model called ELRL-MD that combines ensemble learning and reinforcement learning (RL) for effective myocarditis diagnosis from CMR images.

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Article Synopsis
  • AI models trained on diverse studies can yield better research insights, but differences in imaging protocols can create inconsistencies that limit data integration.
  • A systematic review analyzed literature from 2013 to 2023 on image harmonization methods used in multi-center medical imaging studies, highlighting various techniques and their benefits.
  • Results showed that image harmonization significantly boosts AI performance across multiple imaging fields, paving the way for enhanced healthcare through standardized data and improved analysis capabilities.*
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Background: Timely detection of neurodevelopmental and neurological conditions is crucial for early intervention. Specific Language Impairment (SLI) in children and Parkinson's disease (PD) manifests in speech disturbances that may be exploited for diagnostic screening using recorded speech signals. We were motivated to develop an accurate yet computationally lightweight model for speech-based detection of SLI and PD, employing novel feature engineering techniques to mimic the adaptable dynamic weight assignment network capability of deep learning architectures.

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Article Synopsis
  • AI techniques are increasingly utilized in medical diagnostics, particularly for early detection of Hypertension (HTN), a significant global health concern.
  • Automated detection methods leverage socio-demographic, clinical, and physiological data, as well as imaging modalities to identify initial and secondary HTN.
  • This systematic review reveals that most studies focus on single-modality approaches, while few explore multi-modal data integration, highlighting the need for future research to enhance early HTN detection systems.
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Background And Aim: Anxiety disorder is common; early diagnosis is crucial for management. Anxiety can induce physiological changes in the brain and heart. We aimed to develop an efficient and accurate handcrafted feature engineering model for automated anxiety detection using ECG signals.

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Today, depression is a common problem that affects many people all over the world. It can impact a person's mood and quality of life unless identified and treated immediately. Due to the hectic and stressful modern life seems to be, depression has become a leading cause of mental health illnesses.

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Insomnia is a prevalent sleep disorder characterized by difficulties in initiating sleep or experiencing non-restorative sleep. It is a multifaceted condition that impacts both the quantity and quality of an individual's sleep. Recent advancements in machine learning (ML), and deep learning (DL) have enabled automated sleep analysis using physiological signals.

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Article Synopsis
  • Sleep staging is crucial for diagnosing sleep disorders, and automating this process can save time and improve accuracy for experts.
  • A new model called MixSleepNet combines 3D convolutional and graph convolutional techniques to analyze various physiological signals (EEG, EMG, EOG, ECG) for better sleep stage classification.
  • The model demonstrated high accuracy, with scores around 0.830 and 0.812 for different datasets, proving its effectiveness compared to expert assessments.
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