Antiproliferative, molecular docking, and bioavailability studies of diarylheptanoids isolated from stem bark of Rox B.

Diarylheptanoids are a major class of plant secondary metabolites characterized by 1, 7-diphenyl heptanes in a seven-member carbon frame. In the present study, diarylheptanoids (garuganins 1, 3, 4 and 5) isolated from stem bark were evaluated for cytotoxic activity against MCF-7 and HCT15 cancer cell lines. Among the tested compounds, garuganin and exhibited the highest cytotoxic activity against HCT15 and MCF-7 with IC 2.