A selective bis-thiophene chalcone-based spectrofluorimetric sensor for Fe.

A highly selective bis thiophene-based chalcone as a chemosensor for detecting Fe metal ions in DMF: HO (9:1). This sensor was selective toward ferric ions over other metal ions with a detection limit in micromolar range.

Analyzing the impact of the size of fluoro and chloro substituents on induced mesomorphism in hydrogen bonded liquid crystals.

Synthesis of new supramolecules with specific properties and realistic applications requires a sound knowledge of the structure-property relationships of the synthesized molecules. Non-covalent interaction like hydrogen bonding is conducive in realizing mesomorphism. The induction of the liquid crystalline character is associated with the strength of hydrogen bonds formed between the interacting components, which are affected by the change of polarity and polarizability of both components upon change in their terminal polar substituents.

Modified Open Anterior Preperitoneal Repair.

Background And Objectives: Modified anterior preperitoneal (mAPP) repair for inguinal hernia (IH) was compared with Lichtenstein repair (LR) and laparoscopic transabdominal preperitoneal (TAPP) repairs.

Methods: IH patients, after exclusions and subsequent matching for age, type, and extent of hernia, were assigned randomly for mAPP, LR or TAPP repair. The same surgical team performed all operations.

New benzisoxazole derivative: A potential corrosion inhibitor for mild steel in 0.5 M hydrochloric acid medium -insights from electrochemical and density functional theory studies.

6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole. HCl (FPBH), a substituted benzisoxazole derivative, was prepared from isonipecotic acid and characterized using various spectroscopic techniques. Using electrochemical examinations such as potentiodynamic polarisation (PDP) and electrochemical impedance spectroscopic (EIS) technique, the corrosion mitigation capabilities of this compound for mild steel (MS) in 0.

Surface-Plasmon-Polaritons for Reversible Assembly of Gold Nanoparticles, In Situ Nanogap Tuning, and SERS.

A transportable reversible assembly of gold nanoparticles (AuNPs) in an aqueous environment addresses the need for in situ surafce-enhanced Raman spectroscopy (SERS) hotspot creation for biological applications. Usually, light-directed AuNP assembly methods use higher laser powers and surfactants and are, hence, unsuitable for biological applications. Here, surface plasmon polaritons-assisted dynamic assembly of AuNPs are demonstrated at laser power density as low as 100 nW µm .

Auxiliary Partial Orthotopic Liver Transplant as a Rescue Procedure for Acute Liver Failure with Extra-Small-for-Size Grafts: A Report of 2 Cases.

Auxiliary partial orthotopic liver transplant is a complex technique whereby a partial liver graft is transplanted in the orthotopic position, leaving behind a portion of the native liver. In acute liver failure, auxiliary partial orthotopic liver transplant serves as a rescue therapy and bridge for the native liver to regenerate. Auxiliary partial orthotopic liver transplant was initially considered a technically challenging procedure with inferior results versus orthotopic liver transplant.

Late Hemorrhage Following Laparoscopic Cholecystectomy.

Background: Excruciating generalized abdominal pain with features suggestive of shock, at the end of the first or early second week after laparoscopic cholecystectomy (LC), is a frightening and formidable diagnostic predicament. This is because the early known complications like biliary leak or vascular injuries are unlikely diagnoses. Hemoperitoneum, is not usually considered, but instead more common occurrences like acute pancreatitis, choledocholithiasis, and sepsis are suspected.

Effect of OH substitution in 3-benzylchroman-4-ones: crystallographic, CSD, DFT, FTIR, Hirshfeld surface, and energy framework analysis.

3-Benzylchroman-4-ones (homoisoflavanones) are oxygen-containing heterocycles with a sixteen-carbon skeleton. They belong to the class of naturally occurring polyphenolic flavonoids with limited occurrence in nature and possess anti-inflammatory, antibacterial, antihistaminic, antimutagenic, antiviral, and angioprotective properties. Recently, we reported the synthesis and anticancer activity studies of fifteen 3-benzylchroman-4-one molecules, and most of them were proven to be effective against BT549 and HeLa cells.

A highly sensitive surface-enhanced Raman scattering substrate prepared on a hydrophobic surface using controlled evaporation.

In the present work, we report the fabrication of a surface-enhanced Raman spectroscopy (SERS) substrate on a simple and easily fabricable hydrophobic surface. The substrates are prepared by slow and fast evaporation of a droplet of silver nanoparticle suspension in water. The corresponding identifiers for two substrates are "s_evp" and "f_evp" respectively.

Refractive index and formaldehyde sensing with silver nanocubes.

We report the synthesis of Ag nanocubes by using a sodium sulfide assisted solvothermal method. Small edge-length nanocubes (32 and 44 nm) were obtained at 145 and 155 °C reaction temperature in the synthesis process. The refractive index sensitivity of synthesized nanocubes was investigated with an aqueous solution of glucose.

COVID-19 and Clinical Trials: Current Challenges and Future Directions.

Background: The outbreak of coronavirus disease (COVID-19) has posed a major threat to people's lives across the globe. It has drastically changed the way we perceive this world. A paradigm shift was observed globally as the world's emphasis shifted to testing, diagnosis, treatment, and developing a coronavirus cure.

Binding Motifs in the Naked Complexes of Target Amino Acids with an Excerpt of Antitumor Active Biomolecule: An Ion Vibrational Spectroscopy Assay.

The structures of proton-bound complexes of 5,7-dimethoxy-4H-chromen-4-one (1) and basic amino acids (AAs), namely, histidine (His) and lysine (Lys), have been examined by means of mass spectrometry coupled with IR ion spectroscopy and quantum chemical calculations. This selection of systems is based on the fact that 1 represents a portion of glabrescione B, a natural small molecule of promising antitumor activity, while His and Lys are protein residues lining the cavity of the alleged receptor binding site. These species are thus a model of the bioactive adduct, although clearly the isolated state of the present study bears little resemblance to the complex biological environment.

Vibronic spectra of jet-cooled 1-methyl-2(1H)-quinolinone studied by Fluorescence spectroscopy and Quantum chemical calculation.

1-methyl-2(1H)-quinolinone (MeQone) forms the framework of several hundred quinolone alkaloid molecules, both natural and synthetic, which are being used in various biological applications. In this work, we present experimental and theoretical spectroscopic investigation on the MeQone in its ground and first electronic excited states. The vibronically resolved fluorescence excitation (FE) spectrum of MeQone is recorded within 700 cm to the electronic origin under the supersonic jet-cooled condition.

Ab initio and NBO studies of methyl internal rotation in 1-methyl-2(1H)-quinolinone: effect of aromatic substitution to 1-methyl-2(1H)-pyridone.

1-methyl-2(1H)-quinolinone (MeQone) forms the framework of several hundred alkaloid molecules both natural and synthetic being used for various biological applications. From chemical structure point of view, the molecules can also be seen as an aromatic ring fused to 1-methyl-2(1H)-pyridone (1-MPY). In this work, we present theoretical investigations on internal rotation of methyl group in MeQone in light of 1-MPY.

Intermolecular dissociation energies of 1-naphthol complexes with large dispersion-energy donors: Decalins and adamantane.

The ground-state intermolecular dissociation energies D(S) of supersonic-jet cooled intermolecular complexes of 1-naphthol (1NpOH) with the bi- and tricycloalkanes trans-decalin, cis-decalin, and adamantane were measured using the stimulated-emission-pumping/resonant two-photon ionization (SEP-R2PI) method. Using UV/UV holeburning, we identified two isomers (A and B) of the adamantane and trans-decalin complexes and four isomers (A-D) of the cis-decalin complex. For 1NpOH·adamantane A and B, the D(S) values are 21.

Benchmark Experimental Gas-Phase Intermolecular Dissociation Energies by the SEP-R2PI Method.

The gas-phase ground-state dissociation energy () of an isolated and cold bimolecular complex is a fundamental measure of the intermolecular interaction strength between its constituents. Accurate values are important for the understanding of intermolecular bonding, for benchmarking high-level theoretical calculations, and for the parameterization of dispersion-corrected density functionals or force-field models that are used in fields ranging from crystallography to biochemistry. We review experimental measurements of the gas-phase () and () values of 55 different M⋅S complexes, where M is a (hetero)aromatic molecule and S is a closed-shell solvent atom or molecule.

Comparative Evaluation of Dexmedetomidine and Pregabalin as Premedication Agent to Attenuate Adverse Hemodynamic and Stress Response in Patients Undergoing Laparoscopic Cholecystectomy.

Background: Laparoscopic cholecystectomy is the most commonly performed laparoscopic procedure. The goal of anesthetic management is to minimize stress response and early discharge. Dexmedetomidine, and pregabalin have been used successfully to attenuate laryngoscopy and intubation response in various surgical procedures.

Face, Notch, or Edge? Intermolecular dissociation energies of 1-naphthol complexes with linear molecules.

The stimulated-emission-pumping/resonant 2-photon ionization (SEP-R2PI) method was used to determine the intermolecular dissociation energies D of jet-cooled 1-naphthol(1NpOH)·S complexes, where S is a linear molecule (N, CO, CO, OCS, NO, and ethyne) or symmetric-top molecule (2-butyne) that contains double or triple bonds. The dissociation energies D(S) are bracketed as follows: 6.68 ± 0.

Intermolecular dissociation energies of hydrogen-bonded 1-naphthol complexes.

We have measured the intermolecular dissociation energies of supersonically cooled 1-naphthol (1NpOH) complexes with solvents S = furan, thiophene, 2,5-dimethylfuran, and tetrahydrofuran. The naphthol OH forms non-classical H-bonds with the aromatic -electrons of furan, thiophene, and 2,5-dimethylfuran and a classical H-bond with the tetrahydrofuran O atom. Using the stimulated-emission pumping resonant two-photon ionization method, the ground-state ( ) values were bracketed as 21.

Intermolecular dissociation energies of dispersively bound complexes of aromatics with noble gases and nitrogen.

We measured accurate intermolecular dissociation energies D of the supersonic jet-cooled complexes of 1-naphthol (1NpOH) with the noble gases Ne, Ar, Kr, and Xe and with N, using the stimulated-emission pumping resonant two-photon ionization method. The ground-state values D(S) for the 1NpOH⋅S complexes with S= Ar, Kr, Xe, and N were bracketed to be within ±3.5%; they are 5.

Single incision laparoscopic cholecystectomy: Less scar, less pain.

Unlabelled: Context and Aims: Our study aims to evaluate the post-operative pain and cosmesis of single-incision laparoscopic cholecystectomy (SILC) in comparison with the standard, 3-port laparoscopic cholecystectomy (SLC) with respect to the length of incision, cosmetic scores, post-operative pain scores and duration of hospital stay.

Settings And Design: This comparative randomised study was conducted in a tertiary care centre teaching hospital between September 2012 and 2014. One hundred and fifty consecutive patients, who qualified as per inclusion criteria, were included in the study.