Publications by authors named "Rajeev H Muni"
Purpose: To investigate the relationships between vision-related functional impairment (VFI) with sociodemographic and healthcare access factors in a representative sample of the United States population.
Methods: Data from the 2017 National Health Interview Survey (NHIS) were used. The NHIS involves responses from the U.
Importance: In-office suprachoroidal viscopexy (SCVEXY) is a relatively new procedure for rhegmatogenous retinal detachment (RRD), but minimal information is available regarding outcomes and safety.
Objective: To report outcomes with in-office SCVEXY for primary acute RRD.
Design, Setting, And Participants: This retrospective case series was conducted at St Michael's Hospital in Toronto, Ontario, Canada from June 2023 to February 2024 among consecutive patients with primary acute RRDs who presented with retinal tears that were reachable with the current in-office SCVEXY technique in the temporal or nasal retina.
Topic: To compare face masking protocols for post-intravitreal injection endophthalmitis (PIE) prophylaxis.
Clinical Relevance: Though mask mandates are lifted, ophthalmologists may question whether continued investment into face masks will influence their PIE rate.
Methods/literature Reviewed: We included comparative studies of PIE incidence by masking policy (i.
Purpose: To investigate the relationship between social determinants of health (SDoH) and the prevalence of age-related macular degeneration (AMD).
Methods: This analysis included adult respondents (>50 years old) from the 2017 National Health Interview Survey (NHIS). The primary outcomes were self-reported diagnosis of AMD and self-reported vision loss due to AMD.
Purpose: To comprehensively investigate the suprachoroidal space (SCS) in the context of rhegmatogenous retinal detachment (RRD) using swept-source optical coherence tomography (SS-OCT).
Methods: We conducted a post hoc analysis of 90 consecutive patients with a primary RRD. Baseline SS-OCT scans were graded for the presence and thickness of the suprachoroidal space.
Purpose: To report the technique and long-term outcomes of patients with giant retinal tear associated retinal detachment (GRT-RD) treated with pneumatic retinopexy (PnR).
Methods: Retrospective cohort study. All patients presenting with GRT-RD with tears in the superior ten-clock hours who underwent primary PnR were included in this study.
Purpose: To investigate the comparative efficacy and safety of half-dose photodynamic therapy (PDT) and half-fluence PDT in the management of chronic central serous chorioretinopathy (cCSCR).
Design: Systematic review and meta-analysis METHODS: A comprehensive literature search was conducted on Ovid MEDLINE, Embase, and the Cochrane Library, covering publications from January 2000 to March 2024. The review focused on studies reporting the efficacy and safety of half-dose PDT compared to half-fluence PDT in treating cCSCR.
Purpose: This study aimed to investigate the relationship between sociodemographic and healthcare access factors with self-reported diabetic retinopathy (DR) prevalence in a nationally representative sample of the United States.
Design: This is a population based, cross-sectional analysis.
Methods: Data from those who answered the question, "Have you ever been told by a doctor or other health professional that you had diabetic retinopathy?" from the 2017 National Health Interview Survey (NHIS) was analyzed through logistic regression to examine the association between DR prevalence and social determinants of health (SDH).
Purpose: Sex bias remains a pervasive reality in academic medicine, often reflected in subtle linguistic choices, which can skew perceptions of competence and perpetuate workplace inequity. This study aims to investigate the relationship between host sex, speaker sex, and speaker introduction practices in ophthalmology grand rounds events.
Design: Cross-sectional study.
Correlation Between Photoreceptor and Vascular Parameters in Diabetic Retinopathy Using Adaptive Optics.
Ophthalmic Surg Lasers Imaging Retina
November 2024
Background And Objective: This study aimed to investigate correlations between photoreceptor and vascular parameters in varying stages of diabetic retinopathy (DR) using adaptive optics (AO) imaging.
Patients And Methods: In this single-center, prospective cohort study, 29 participants (46 eyes) were classified into control/mild non-proliferative DR (NPDR), moderate/severe NPDR, and proliferative DR. AO images of photoreceptors and retinal vasculature were analyzed, and Spearman's correlation (ρ) was used to assess relationships between photoreceptor density and vascular parameters.
Objective: To describe the sequential morphological changes of the outer retina after full-thickness macular hole (FTMH) formation utilizing a novel, objective staging system based on OCT, and to determine its association with baseline visual acuity, duration of symptoms, and postoperative visual acuity at 3 months.
Design: Retrospective, observational, multicenter study.
Participants: Patients with idiopathic FTMH presenting to St.
Article Synopsis
- This study evaluated the photoreceptor mosaic in patients with idiopathic full thickness macular holes before and after surgery using adaptive optics imaging.* -
- Conducted at the Kensington Eye Institute, the research excluded patients with certain conditions and involved detailed measurements of cone density and regularity in the retina.* -
- Results showed a significant decrease in cone density and changes in spacing and dispersion three months post-surgery, demonstrating the effectiveness of adaptive optics for assessing retinal health.*
Article Synopsis
- A new positioning technique, known as the mini-steamroll maneuver, is introduced for patients with retinal detachment after a procedure called pneumatic retinopexy (PnR).
- The study involved six patients and showed that the maneuver, which includes a face-down position for 10 minutes, significantly reduced subretinal fluid and aided in retinal reattachment.
- The findings suggest that the mini-steamroll maneuver could be an effective and simpler alternative for patient positioning post-PnR in specific cases.
Article Synopsis
- Intravitreal anti-VEGF therapy is a key treatment for retinal diseases, but the effectiveness and safety of new bispecific agents like faricimab compared to traditional monoclonal anti-VEGF agents is still uncertain.
- A systematic review of studies from 2015 to 2024 analyzed outcomes from 13 studies involving both faricimab and standard anti-VEGF therapy, focusing on visual acuity, central subfield thickness, and adverse events.
- Results showed no significant difference in visual acuity between the two treatments, but faricimab reduced central subfield thickness more effectively in cases of diabetic macular edema and retinal vein occlusion, with similar rates of ocular side effects across both agent types.
Article Synopsis
- The study aimed to find out what factors can predict how well a person's vision will be after surgery for a specific type of eye problem called rhegmatogenous retinal detachment.
- Researchers tested patients' vision, focusing on problems like seeing things distorted (metamorphopsia) and differences in image size between both eyes (aniseikonia) three months after their surgery.
- They found that damage to certain parts of the retina seen in special eye images was linked to worse vision outcomes after the surgery.
Objective: To compare visual outcomes and complication risk based on the timing of pars plana vitrectomy (PPV) following cataract surgery with retained lens fragments.
Methods: MEDLINE (Ovid), EMBASE, and Cochrane Library were searched between 2000 to February 2022 for studies comparing visual outcomes and complications based on time to PPV. Discrete outcomes were analyzed using a random-effects meta-analysis model on Review Manager (RevMan 5.
Evaluation of Pars Plana Vitrectomy With and Without Supplemental Scleral Buckle for the Repair of Rhegmatogenous Detachment Due to Inferior Retinal Breaks: A Systematic Review.
Ophthalmic Surg Lasers Imaging Retina
August 2024
In this systematic review, the efficacy of scleral buckle (SB) with pars plana vitrectomy (PPV) was compared to PPV alone in eyes with rhegmatogenous retinal detachment (RRD) due to inferior retinal breaks (IRB). Measured outcomes included final best-corrected visual acuity (BCVA), anatomic success, and complication rates in randomized controlled trials and observational studies from 2000 to 2022. Among four studies (696 eyes), three studies demonstrated no significant difference between PPV and PPV/SB for final BCVA, whereas one study reported better BCVA with added SB.
View Article and Find Full Text PDFObjective: To examine the association between quantitative vascular parameters extracted from intravenous fluorescein angiography (IVFA) and baseline clinical characteristics of patients with retinal vein occlusion (RVO).
Methods: Our prospective single-centre study in Toronto, Canada, recruited patients with a diagnosis of macular edema secondary to RVO presenting with a central macular thickness (CMT) ≥310 μm from 2017 to 2023. IVFA images were captured using an ultra-widefield scanning laser ophthalmoscope and processed using the artificial intelligence-based RETICAD system to extract quantitative measurements of blood flow, perfusion, and blood-retinal barrier (BRB) permeability.
Purpose: To assess long-term redetachment rates of the Pneumatic Retinopexy versus Vitrectomy for the Management of Primary Rhegmatogenous Retinal Detachment Outcomes Randomized Trial (PIVOT).
Design: Randomized controlled trial.
Subjects: PIVOT trial participants.
Purpose: To investigate associations between quantitative vascular measurements derived from intravenous fluorescein angiography (IVFA) and baseline characteristics on optical coherence tomography (OCT) in neovascular age-related macular degeneration (nAMD) patients.
Methods: The authors prospectively recruited patients with active choroidal neovascularization secondary to AMD over 50 years old, presenting to a single center in Toronto, Canada from 2017 to 2023. Ultra-widefield IVFA images were processed using the artificial intelligence RETICAD FAassist system to extract quantitative information on blood flow, perfusion, and blood-retinal-barrier (BRB) permeability.
Article Synopsis
- This study compares the primary reattachment rate (PARR) of two treatments, pneumatic retinopexy (PnR) and pars plana vitrectomy (PPV), for patients with a specific type of retinal detachment.
- It included 162 patients, where PARR was shown to be similar: 88.2% for PnR and 90.9% for PPV, with PnR providing better visual acuity outcomes.
- The findings suggest that PnR can be considered a suitable first-line treatment for select patients, as it yields similar reattachment rates while enhancing visual recovery.