Spectrochim Acta A Mol Biomol Spectrosc
March 2025
Supercapacitors (SCs) are well recognized for their excessive power output and cycling stability, but they often suffer from limited energy density. A promising solution to this challenge is the hybrid supercapattery (HSC) concept, which integrates two different electrodes with disparate charge-storage systems to provide energy and power. In this work, transition-metal phosphides (TMPs), specifically a Cu-doped cobalt phosphide wrapped with an N-doped porous carbon network (CCP-NPC), were used as positive electrode materials in HSCs.
View Article and Find Full Text PDFIn this report, a functionalized hydroxyphenyl benzothiazole (HBT) derivative has been synthesized and anchored onto the perylene diimide (PDI) core at the -bay position (PHI). PHI has been explored for the generation of radical anions (PH1˙-) and dianions (PH12-) in 20% HEPES buffer-DMSO solution using HS as a sacrificial electron donor. The PH1˙- has a half-life () of 1.
View Article and Find Full Text PDFThe efficacy of any electrochemical reaction hinges on the extent of interaction achievable between reactive intermediates and the electrocatalytic active site. Any weak adsorption of these intermediates on the metal's active site results in low oxygen evolution reaction (OER) rates, mainly when catalysed by the Ni-based layered double hydroxide. To tackle this challenge, a heterojunction consisting of nickel-iron layered double hydroxide (NiFe-LDH) and cerium trifluoride (CeF) is synthesized.
View Article and Find Full Text PDFOne of the most coveted objectives in the realm of energy conversion technologies is the development of highly efficient and economically viable electrocatalysts for the oxygen evolution reaction. The commercialization of such techniques has thus far been impeded by their slow response kinetics. One of the many ways to develop highly effective electrocatalysts is to judiciously choose a coupling interface that maximizes catalyst performance.
View Article and Find Full Text PDFGrape leaves, scientifically known as the primary by-product obtained after the processing of grapes, are gathered in enormous amounts and disposed of as agricultural waste. For more sustainable agriculture and better food systems, it is crucial to investigate these byproducts' nutritional values. The primary bioactive compounds present in grape leaves are quercetin, resveratrol, caffeic acid, kaempferol, and gallic acid, which favour pharmacological effects on human health such as antioxidant, anti-inflammatory, anti-obesity, anti-diabetic, and hepatoprotective.
View Article and Find Full Text PDFComposite lymphoma implies the presence of two or more morphological and immunophenotypical subtypes of lymphoma in a single tissue or organ. Composite lymphoma with concurrent mantle cell lymphoma (MCL) and classical Hodgkin lymphoma is extremely rare. In this case report, we present the case of a 70-year-old male who was diagnosed with a composite of MCL and classical Hodgkin lymphoma (cHL) and achieved near-complete resolution with chemoimmunotherapy.
View Article and Find Full Text PDFAppl Biochem Biotechnol
July 2024
Globally, lung cancer contributes significantly to the public health burden-associated mortality. As this form of cancer is insidious in nature, there is an inevitable diagnostic delay leading to chronic tumor development. Non-small cell lung cancer (NSCLC) constitutes 80-85% of all lung cancer cases, making this neoplasia form a prevalent subset of lung carcinoma.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2023
The potential for water splitting electrocatalysts with high efficiency paves the way for a sustainable future in hydrogen energy. However, this task is challenging due to the sluggish kinetics of the oxygen evolution reaction (OER), which has a significant impact on the hydrogen evolution reaction (HER). Herein multi-heterointerface of NiP-NiP@NiS was fabricated by a two-step synthesis procedure that consist the development of NiP-NiP nanosheets over nickel foam followed by the electrodeposition of NiS.
View Article and Find Full Text PDFAmyloid-β (Aβ) aggregation and β-amyloid precursor protein cleaving enzyme 1 (BACE1) are the potential therapeutic drug targets for Alzheimer's disease (AD). A recent study highlighted that tacrine-benzofuran hybrid C1 displayed anti-aggregation activity against Aβ peptide and inhibit BACE1 activity. However, the inhibition mechanism of C1 against Aβ aggregation and BACE1 activity remains unclear.
View Article and Find Full Text PDFRev Endocr Metab Disord
August 2023
Technology impacts human life in both the aspects such as positive and negative, which helps in better communication and eliminating geographical boundaries. However, social media and mobile devices may lead to severe health conditions such as sleep problems, depression, obesity, etc. A systematic review is conducted to analyze health issues by tracking food intake by considering positive aspects using Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Guidelines.
View Article and Find Full Text PDFHere, in the present work, a new hydroxybenzothiazole derivative () with AIE+ESIPT features was synthesized by Suzuki-Miyora coupling of with 4-formylphenylboronic acid. The AIE and ESIPT features were confirmed by optical, microscopic (AFM) and dynamic light scattering (DLS) techniques. The yellow fluorescent aggregates of can specifically detect Cu/Cu ions with limits of detection as low as 250 nM and 69 nM.
View Article and Find Full Text PDFPurpose: Carbapenemases are the enzymes that can hydrolyze carbapenems and other β-lactam antibiotics. These enzymes confer resistance to multiple antibiotics and act as a stumbling block in the treatment of infections caused by gram-negative bacteria. Therefore, rapid and specific detection of these enzymes is crucial for deciding the course of treatment and better clinical outcomes.
View Article and Find Full Text PDFBackground: An unhealthy diet or excessive amount of food intake creates obesity issues in human beings that further may cause several diseases such as Polycystic Ovary Syndrome (PCOS), Cardiovascular disease, Diabetes, Cancers, etc. Obesity is a major risk factor for PCOS, which is a common disease in women and is significantly correlated with weight gain.
Methods: This study is providing a one-step solution for predicting the risk of obesity using different Machine Learning (ML) algorithms such as Gradient Boosting (GB), Bagging meta-estimator (BME), XG Boost (XGB), Random Forest (RF), Support Vector Machine (SVM), and K Nearest Neighbour (KNN).
Aim: To evaluate the pathogenic variants in GCDH gene and to assess the neurodevelopmental outcomes in children with Glutaric aciduria type 1 (GA-1).
Method: Cross-sectional observational study between January 2019 and June 2020 in consecutive North Indian children with a clinical and biochemical suspicion of GA-1. Variants in the coding regions of GCDH gene were identified through Sanger sequencing.
The pharmacokinetics of ampicillin-cloxacillin, given as single intravenously dose of 10 mg.kg (5 mg.kg of ampicillin plus 5 mg.
View Article and Find Full Text PDFCardiovascular disorders are the leading cause of death globally. Rosuvastatin is a member of statins (inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase) with many pleiotropic properties. This study investigated cardioprotective effects of rosuvastatin in isoprenaline-induced myocardial injury.
View Article and Find Full Text PDFBackground: Inosine triphosphate pyrophosphohydrolase (ITPase) deficiency associated with mutations in the gene is a recently characterized purine pathway defect that presents with early infantile epileptic encephalopathy and lethal course. This disorder is rare, and only 12 cases are reported worldwide.
Methods: We report two additional cases of -associated neurodegeneration and two pathogenic compound heterozygous variants.
Hyperprolinemia type II (HPII) is a rare autosomal recessive disorder of proline degradation pathway due to deficiency of delta-1-pyrroline-5-carboxylate dehydrogenase. Pathogenic variants in the ALDH4A1 gene are responsible for this disorder. We here describe an 11-month-old infant with recurrent seizures refractory to multiple antiepileptic drugs.
View Article and Find Full Text PDFCobalamin C defect is caused by pathogenic variants in the MMACHC gene leading to impaired conversion of dietary vitamin B into methylcobalamin and adenosylcobalamin. Variants in the MMACHC gene cause accumulation of methylmalonic acid and homocysteine along with decreased methionine synthesis. The spectrum of MMACHC gene variants differs in various populations.
View Article and Find Full Text PDFThe unprecedented application of pesticides in Punjab, India during green revolution has lead to an environmental crisis due to the accumulation of persistent organic and pesticide pollutants in the environment and biota of this region. The present study aimed at estimating the abundance of pesticide contaminants in three biological matrices of 36 dogs suffering from malignant canine mammary tumor (mCMT) and 6 tumor free control dogs from Punjab, India. Presence of individual and total pesticides in canine biological samples, age and bodyweight of canine patients was assessed as a potential risk factor for mCMT using logistic regression analysis.
View Article and Find Full Text PDFClassical homocystinuria is the most common cause of isolated homocystinuria. The variants of the CBS gene remain unidentified in Indian children with this disorder. Based on the hallmark clinical features, family history, and/or biochemical clues for classical homocystinuria, 16 children below the age of 18 years were evaluated by Sanger sequencing of the coding exons of CBS gene with flanking intronic regions.
View Article and Find Full Text PDFAim: The present study was designed to investigate the role of nitric oxide (NO) in the non-development of stress adaptation in high-intensity foot-shock stress (HIFS) subjected mice.
Methods: Mice were subjected to low-intensity shocks (LIFS i.e.
Cardiovascular disorders constitute the principal cause of deaths worldwide and will continue as the major disease-burden by the year 2060. A significant proportion of heart failures occur because of use and misuse of drugs and most of the investigational agents fail to achieve any clinical relevance. Here, we investigated rosuvastatin and retinoic acid for their "pharmacological pleiotropy" against high dose β-adrenergic agonist (isoproterenol)-induced acute myocardial insult.
View Article and Find Full Text PDF