Klebsiella pneumoniae Glycoconjugate Vaccine Leads Based on Semi-Synthetic O1 and O2ac Antigens.

Klebsiella pneumoniae (KP) is a common opportunistic pathogen that emerged as a new critical threat to human health, due to its hypervirulence and widespread resistance against many antibiotics, including carbapenems. Alternative intervention strategies such as vaccines are not available. Cell-surface lipopolysaccharides (LPS) and capsular polysaccharides (CPS) are attractive targets for vaccine development.

Congenital Segmental Dilatation of Ascending Colon with Distal Microcolon: A Diagnostic Dilemma.

A 5-day-old male presented with bilious vomiting, a grossly distended abdomen, and passage of a small amount of stool. The anal opening was at a normal position. X-ray abdomen showed a large bowel loop with a single air-fluid level occupying more than half of the abdominal width.

Synthesis of oligosaccharides to identify an immunologically active epitope against infection.

() is an emerging multidrug-resistant fungal pathogen that represents a significant public health challenge as it can spread rapidly and result in high mortality rates. The mannans on the cell surface are potent immunogens and attractive targets for developing a glycoconjugate vaccine. We synthesized the oligosaccharides resembling cell surface mannans of and printed them onto microarray slides that were used to screen plasma from mice infected with .

Numerical Analysis of Coronavirus Detection Using Photonic Crystal Fibre-Based SPR Sensor.

Coronavirus disease (COVID-19) is a worldwide health emergency caused by the coronavirus 2 (severe acute respiratory illness) (SARS-CoV-2). COVID-19 has a wide range of symptoms, making a definitive diagnosis difficult. The shortage of equipment for testing technology COVID-19 has resulted in long queues for COVID-19 testing, which is a major problem.

Synthesis of Oligosaccharides Resembling the Serotype 18 Capsular Polysaccharide as a Basis for Glycoconjugate Vaccine Development.

Here we report the first total synthesis of several oligosaccharides resembling the capsular polysaccharide of swine pathogen serotype 18 repeating unit [→3)-d-GalNAc(α1-3)[d-Glc(β1-2)]-d-GalA4OAc(β1-3)-d-GalNAc(α1-3)-d-BacNAc4NAc(α1→]. Access to the pentasaccharide repeating unit antigen proved to be very challenging due to the poor reactivity in the context of the trisaccharide. The challenge was overcome by the creation of a galacturonic acid in a late stage of the synthesis.

Palladium-Catalyzed Direct C2-Biarylation of Indoles.

Biaryl and indole units are important structural motifs in several bioactive molecules and functional materials. We have accomplished straightforward access to C2-biarylated indole derivatives through palladium-catalyzed C-H activation strategy with a broad range of substrate scope in yields of 24 to 92%. Besides, the UV/visible absorption and fluorescence properties of the ensuing products were explored.

Base-promoted 1,6-conjugate addition of alkylazaarenes to para-quinone methides.

1,1,2-Triarylethanes embedded with an azaarene unit were prepared in a single step at ambient temperature via the sodium hexamethyldisilazide mediated 1,6-conjugate addition of unactivated alkylazaarenes on para-quinone methides (p-QMs). The extent of this methodology was investigated with a wide range of p-QMs and alkylazaarenes, and the respective products were obtained in moderate to excellent yields. The regioselective 1,6-conjugate addition of the trialkylazaarene precursor on para-quinone methide was also presented.

Bochdalek's hernia in an elderly male - A case report.

Diaphragmatic hernia is protrusion of the abdominal contents into the thoracic cavity. It is a congenital defect of the diaphragm. It is most commonly encountered in infancy but rarely in adults.

Multichannel Decoded Local Binary Patterns for Content-Based Image Retrieval.

Local binary pattern (LBP) is widely adopted for efficient image feature description and simplicity. To describe the color images, it is required to combine the LBPs from each channel of the image. The traditional way of binary combination is to simply concatenate the LBPs from each channel, but it increases the dimensionality of the pattern.

Local Wavelet Pattern: A New Feature Descriptor for Image Retrieval in Medical CT Databases.

A new image feature description based on the local wavelet pattern (LWP) is proposed in this paper to characterize the medical computer tomography (CT) images for content-based CT image retrieval. In the proposed work, the LWP is derived for each pixel of the CT image by utilizing the relationship of center pixel with the local neighboring information. In contrast to the local binary pattern that only considers the relationship between a center pixel and its neighboring pixels, the presented approach first utilizes the relationship among the neighboring pixels using local wavelet decomposition, and finally considers its relationship with the center pixel.

Rotation and illumination invariant interleaved intensity order-based local descriptor.

The region descriptors using local intensity ordering patterns have become more popular recent years for image matching due to its enhanced discriminative ability. However, the dimension of these descriptors increases rapidly with the slight increase in the number of local neighbors under consideration and becomes unreasonable for image matching due to time constraint. In this paper, we reduce the dimension of the descriptor and matching time significantly while keeping up the comparable performance by considering the number of neighboring sample points in an interleaved manner.

To Evaluate Cytotoxicity of Resin-based Restorative Materials on Human Lymphocytes by Trypan Blue Exclusion Test: An in vitro Study.

The cytotoxicity of a resin-based material can be evaluated on isolated human lymphocyte. Since resin-based dental materials have been used with increasing frequency in anterior and posterior teeth restorations, the uncured resin monomers are leached out from the restorations and diffuses into the dentine and ultimately hampers the odontoblastic layers of pulp as well as gingiva. It is also reaches into the saliva and circulatory blood.