Influence of L-Carnitine on Stored Rat Blood: A Study on Plasma.

Objective: Plasma acts as a good indicator of oxidative stress in blood. L-Carnitine is an antioxidant that reduces metabolic stress in cells, thereby providing a protective effect against oxidative stress (OS). L-Carnitine as an additive in storage has not been explored.

Prospects of curcumin as an additive in storage solutions: a study on erythrocytes.

Background/aim: Curcumin, a naturally occurring antioxidant, shows a wide variety of medicinal properties. The possibility of utilizing curcumin as an additive in storage solutions of blood has not been explored. The purpose of this study was to analyze the effect of curcumin on erythrocytes during storage.

Oxidative stress in erythrocytes of banked ABO blood.

Objective: To understand the responses of A, B, and O blood groups to oxidative stress (OS) induced through storage.

Methods: A, B, and O blood units were obtained from the blood bank at KIMS Hospital, Bangalore, and stored for 35 days at 4°C in citrate phosphate dextrose adenine-1 solution. Every fifth day, hemoglobin (Hb) was assessed in whole blood and erythrocytes were isolated from each group.

CUPRAC-BCS and antioxidant activity assays as reliable markers of antioxidant capacity in erythrocytes.

Objective: The CUPRAC-BCS and antioxidant activity (AOA) assays have been developed as indirect methods to determine the total antioxidant capacity (TAC). We examined these assays as markers, in erythrocytes, under oxidative stress (induced by storage) and with antioxidants--vitamin C, L-carnitine, and curcumin.

Methods: Antioxidants were added to blood samples, stored and assayed for TAC and reactive oxygen species (ROS).

Curcumin as a modulator of oxidative stress during storage: a study on plasma.

Background: Plasma reflects the situations of oxidative stress in blood. Curcumin as an additive in storage solutions is not explored.

Materials And Methods: Blood was drawn from male Wistar rats (4 months old) and stored over a period of 20 days at 4 °C in CPDA-1.

The efficacy of erythrocytes isolated from blood stored under blood bank conditions.

Background: The RBCs storage lesion is most carefully viewed as the sum of all the changes in RBCs occurring during the course of storage and that limit their survival.

Materials And Methods: Erythrocytes were isolated from stored blood at regular intervals. Oxidative stress markers were analyzed to determine the changes during the storage.