Oxidative modulations in platelets stored in SSP+, PAS-G and Tyrode's buffer: a comparative analysis.

Background: Platelet additive solutions (PASs) improve the efficacy of stored platelets. Oxidative stress causes storage lesions and platelet functions deteriorate. Studies assessing the influence of oxidative stress on platelets stored in PASs are limited.

Differential Responses of Young and Old Erythrocytes Stored with Vitamin C and Vitamin E in Additive Solution-7.

Oxidative stress (OS) causes biochemical and morphological alterations in erythrocytes. The primary factors contributing to OS are aging and storage. Antioxidants significantly alleviate OS.

Attenuation of Oxidative Stress in Erythrocytes Stored with Vitamin C and l-Carnitine in Additive Solution-7.

Blood transfusion has advanced toward component therapy for specific requirements during trauma and surgery. Oxidative stress is induced in erythrocytes during storage. Hence, antioxidants as additives can be employed to counteract oxidative stress and enhance antioxidant defenses.

Platelet storage: Progress so far.

There is a crucial need for platelet transfusion during an emergency-surgery and treatment of platelet disorders. The unavailability of donors has furthermore increased the demand for platelet storage. Platelets have limited shelf life due to bacterial contamination and storage lesions.

Synergistic activity of vitamin-C and vitamin-E to ameliorate the efficacy of stored erythrocytes.

Objectives: Erythrocytes are exposed to oxidative stress during storage and can be stored for up to 42 days (in AS-7) under blood bank conditions for transfusion. Vitamin-C and Vitamin-E have proved beneficial in diminishing oxidative stress. Therefore, this study aims to investigate the combined effects of Vitamin-C and Vitamin-E on erythrocytes during storage.

Effects of rejuvenation on young and old erythrocytes of banked blood towards the end of storage period.

The effects of rejuvenation on the subpopulation of stored erythrocytes have not been explored. This study aims at determining the influence of rejuvenation on young and old erythrocytes of stored blood. Prior studies have shown the disappearance of young cells after day 20 of storage.

Influence of AS-7 on the storage lesion in young and old circulating erythrocytes.

Blood and its components are stored to meet the demands of blood transfusion. Erythrocytes undergo progressive modifications during storage known as storage lesions. Storage solutions were developed to improve shelf life and extend red cell viability.

Effects of L-carnitine on the erythrocytes of stored human blood.

Objectives: This study aimed to assess the effects of L-carnitine on oxidative stress in human erythrocytes during storage.

Background: Using antioxidants as components of blood storage solutions may combat the effects of storage-induced oxidative stress on erythrocytes.

Methods: Blood from male adults was stored at 4 °C for 55 days in citrate phosphate dextrose adenine solution, without L-carnitine (Control) and with L-carnitine as an additive (at concentrations of 10, 30 and 60 mM - Experiments).

Age-Related Modulations in Erythrocytes under Blood Bank Conditions.

Background: During storage of erythrocytes, storage lesions are formed that reduce the safety and efficacy of the stored blood. Thus, there is a need to understand the changes that occur during storage. Most studies have focused on storage of a mixed population of erythrocytes.

L-Carnitine as an additive in Tyrode's buffer during platelet storage.

: Platelets are stored at 22-24°C for 5 days, with gentle agitation. Platelet storage lesion decreases efficacy and safety of stored platelets. L-Carnitine is a nonessential amino acid.

Platelet disorders: an overview.

Thrombocytes or platelets are anucleated cells derived from megakaryocytes by process of megakaryopoiesis, with maturation time of 4-5 days. They are small and discoid in shape with size ranging from 2 to 4 μm. The platelet concentration in blood varies between 150, 000 and 400, 000  cells/μl of blood.