Effect of urinary tract infection on the outcome of the allograft in patients with kidney transplantation.

Background: Urinary tract infections (UTIs) are the second most common cause of graft dysfunction, accounting for significant morbidity, and are associated with poor graft and patient survival. This study aimed to assess the association between post-renal transplant UTI and graft outcomes.

Methods: We examined the effect of UTIs on graft outcomes in patients who underwent renal transplantation surgery between January 2010 and December 2022.

Peripheral blood smear - An expeditious test in the preliminary diagnosis of bone marrow embolism in a case of multiple fractures: A case report.

Bone marrow embolism is known to occur after fractures of long bones such as the femur and pelvis. We report a case of multiple fractures in a 32-year-old female patient, demonstrating bone marrow elements in the peripheral blood as early as 2 hours after trauma. This is the first case being reported with an ante-mortem demonstration of circulating marrow emboli in the peripheral blood, while the previously reported cases have demonstrated the emboli in post-mortem examination.

Bioinformatic Tools for the Identification of MicroRNAs Regulating the Transcription Factors in Patients with β-Thalassemia.

β-thalassemia is a significant health issue worldwide, with approximately 7% of the world's population having defective hemoglobin genes. MicroRNAs (miRNAs) are short noncoding RNAs regulating gene expression at the post-transcriptional level by targeting multiple gene transcripts. The levels of fetal hemoglobin (HbF) can be increased by regulating the expression of the γ-globin gene using the suppressive effects of miRNAs on several transcription factors such as MYB, BCL11A, GATA1, and KLF.

Non-diabetic Kidney Disease in Diabetic Population: A Single-Center Study From South India.

Introduction: Diabetic kidney disease (DKD) is the commonest cause of chronic kidney disease and end-stage kidney disease worldwide, consequently it has become an important productive implication to the healthcare system. This study was conducted to assess the prevalence of non-DKD (NDKD) in diabetic patients from south India.

Objective: To assess the prevalence of NDKD in type 2 diabetes mellitus patients presenting to a tertiary care hospital from south India and also to analyze clinical clues to establish a diagnosis of NDKD.

Compliance to anti-rabies vaccination in post-exposure prophylaxis.

Complete post-exposure prophylaxis is necessary to prevent rabies among all animal bite victims. It is essential for the bite victims to complete the full course of vaccination as recommended for complete protection. The present study was conducted to determine the compliance rate for anti-rabies vaccination by both intramuscular route and intradermal route and to determine the major constraints.

Live cell imaging reveals novel functions of Salmonella enterica SPI2-T3SS effector proteins in remodeling of the host cell endosomal system.

Intracellular Salmonella enterica induce a massive remodeling of the endosomal system in infected host cells. One dramatic consequence of this interference is the induction of various extensive tubular aggregations of membrane vesicles, and tubules positive for late endosomal/lysosomal markers are referred to as Salmonella-induced filaments or SIF. SIF are highly dynamic in nature with extension and collapse velocities of 0.

Reorganization of the endosomal system in Salmonella-infected cells: the ultrastructure of Salmonella-induced tubular compartments.

During the intracellular life of Salmonella enterica, a unique membrane-bound compartment termed Salmonella-containing vacuole, or SCV, is formed. By means of translocated effector proteins, intracellular Salmonella also induce the formation of extensive, highly dynamic membrane tubules termed Salmonella-induced filaments or SIF. Here we report the first detailed ultrastructural analyses of the SCV and SIF by electron microscopy (EM), EM tomography and live cell correlative light and electron microscopy (CLEM).

Dynamic modification of microtubule-dependent transport by effector proteins of intracellular Salmonella enterica.

Intracellular Salmonella enterica translocate effector proteins that modify microtubule-dependent transport processes of the host cell and modulate the biogenesis of the Salmonella-containing vacuole (SCV). One functional consequence is the induction of tubular aggregates of endosomal membranes, termed Salmonella-induced filaments or SIFs, and further tubular membrane compartments have recently been described. SIFs are unique, highly dynamic compartments that form by modification of vesicular transport on microtubules.

Dynamic remodeling of the endosomal system during formation of Salmonella-induced filaments by intracellular Salmonella enterica.

The infection by Salmonella enterica results in the massive remodeling of the endosomal system of eukaryotic host cells. One unique consequence is the formation of long tubular endosomal compartments, so-called Salmonella-induced filaments (SIF). Formation of SIF requires the function of type III secretion system and is a requirement of efficient intracellular proliferation of Salmonella.

Blood pressure response to cold pressor test in siblings of hypertensives.

One hundred and five female and thirty-four male student volunteers were divided into three groups. Each group was again divided into siblings of hypertensives (SH) and siblings of normotensives (C). SH group had higher basal seated and supine Systolic and Diastolic Blood Pressures (SBPs and DBPs, respectively).

HLA antigens in South India: I. Major groups of Tamil Nadu.

HLA-A, B profile of 385 normal healthy individuals living in Tamil Nadu, India was studied by microlymphocytotoxicity testing. Antigen, gene and haplotype frequencies of this population were calculated and compared to those already available in the literature. The sample was further divided into four major groups and the frequencies calculated.