Publications by authors named "Rajashekar B"

Invasive alien species (IAS) pose a severe threat to global agriculture, with their impact projected to escalate due to climate change and expanding international trade. The fall armyworm (FAW), Spodoptera frugiperda (J. E.

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The aim of the study was to find the association of various risk factors with permanent hearing impairment in infants. A case-control study was designed on 420 infants with permanent hearing impairment and normal hearing. The case control ratio was 1:1.

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Article Synopsis
  • The study aimed to assess blood pressure in Indian children aged 5 to 12 from different altitudes, comparing those near sea level to those living at higher elevations in the Himalayas.
  • Using trained doctors, blood pressure was measured in 1,229 children, revealing a significant increase in both systolic and diastolic readings as altitude increased.
  • The findings suggest that blood pressure readings in children vary with altitude, providing important information for better interpretation of these readings in high-altitude populations.
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Background: The preschool children hardly complain about their vision problems. It is of paramount importance to screen them with an objective tool and compare with the gold standard technique.

Aim: To compare the values obtained with Plusoptix A09 and cycloplegic refraction in 3-6 years children and agreement to detect refractive amblyogenic risk factors.

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Soil microorganisms play a critical role in soil biogeochemical processes, nutrient cycling, and resilience of agri-food systems and are immensely influenced by agronomic management practices. Understanding soil bacterial community and nutrient dynamics under contrasting management practices is of utmost importance for building climate-smart agri-food systems. Soil samples were collected at 0-15 cm soil depth from six management scenarios in long-term conservation agriculture (CA) and climate-smart agriculture (CSA) practices.

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is an endangered western Asiatic desert plant species, which survives under extreme environmental conditions. In this study, we focused on transcriptome analysis of to understand the molecular mechanisms associated with drought tolerance. Two different periods of polyethylene glycol (PEG)-induced drought stress (48 h and 72 h) were imposed on under in vitro conditions, which resulted in 18 million reads, subsequently assembled by de novo method with more than 8000 transcripts in each treatment.

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In this review we present the developmental, histological, evolutionary and functional properties of insect chemosensory proteins (CSPs) in insect species. CSPs are small globular proteins folded like a prism and notoriously known for their complex and arguably obscure function(s), particularly in pheromone olfaction. Here, we focus on direct functional consequences on protein function depending on duplication, expression and RNA editing.

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Background: Preschool vision screenings are considered to be cost-effective methods to identify children with vision disorders. The children of this age group are poor at communicating their symptoms and hence screening is mandated. This study is aimed at estimating the diagnostic accuracy and agreement of Lea, HOTV and E visual acuity charts for detecting significant refractive errors.

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In Indo-Gangetic plains (IGP) of India, natural resources (soil, water, and environment) are degrading under the conventional-till (CT)-based management practices in rice-wheat cropping system. A long-term field experiment was conducted to understand the soil bacterial diversity and abundance under different sets of management scenarios (Sc). The study comprised of four scenarios, namely, -Sc.

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Hepatocellular carcinoma (HCC) typically develops in a chronic inflammatory setting causal to release of a plethora of growth factors and cytokines. However, the molecular effect of these cytokines on HCC progression is poorly understood. In this study, we exposed HCC cells to TGF-β2 (Transforming Growth Factor-β2), which resulted in a significant elevation of EMT (Epithelial to Mesenchymal Transition) like features.

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Tissue-engineering-based three-dimensional (3D) models offer several advantages over conventional two-dimensional (2D) cultures and can mimic tissues in vivo. Although studies have analyzed the changes in the expression of genes and proteins that might mediate in vivo-like signaling, the changes in the post-transcriptional control of gene expression that are critical in fine-tuning of signaling events has never been studied. In this study, we used next-generation sequencing (NGS) to analyze the changes in the post-transcriptional regulation in MDA-MB-231 breast cancer cells cultured on 3D scaffolds.

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We present the complete mitochondrial genome of honey bee subspecies, (Apidae) belonging to the African lineage. The assembled circular genome has a length of 16,569 bp which comprises 13 protein coding genes, 22 transfer RNA genes, two ribosomal RNA genes, and AT rich region.

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Specific Language Impairment (SLI) remains an underinvestigated disorder in morphologically complex agglutinative languages such as Kannada. Currently, only a few case reports are available on SLI in Dravidian languages. The morphological complexity inherent to Dravidian languages such as Kannada provides a potential avenue to verify one of the two prevailing accounts of SLI: the morphological richness theory and CGC (Computational Grammatical Complexity) hypothesis.

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Objective: Among the stimulus factors, the influence of presentation level is less studied in normal-hearing individuals when using speech stimuli withvarious presentation levels for the auditory late latency response (ALLR). Hence, the present study aimed to explore the Latency-Intensity (L-I) function, i.e.

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Chemosensory proteins (CSPs) are believed to play a key role in the chemosensory process in insects. Sequencing genomic DNA and RNA encoding CSP1, CSP2 and CSP3 in the sweet potato whitefly Bemisia tabaci showed strong variation between B and Q biotypes. Analyzing CSP-RNA levels showed not only biotype, but also age and developmental stage-specific expression.

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Article Synopsis
  • Endometrial DNA methylation changes may contribute to endometriosis, but are influenced by the menstrual cycle, requiring careful analysis of hormonal cycles when studying related disorders.
  • A study compared DNA methylation profiles from endometrial tissues of women with endometriosis and healthy controls across different menstrual phases, finding only 28 distinct methylation differences that were minimal overall.
  • The findings highlight that menstrual cycle phases significantly affect epigenetic profiles, suggesting that any disease-specific methylation patterns must account for these normal cycle-related changes.
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Given the possible critical importance of placental gene imprinting and random monoallelic expression on fetal and infant health, most of those genes must be identified, in order to understand the risks that the baby might meet during pregnancy and after birth. Therefore, the aim of the current study was to introduce a workflow and tools for analyzing imprinted and random monoallelic gene expression in human placenta, by applying whole-transcriptome (WT) RNA sequencing of placental tissue and genotyping of coding DNA variants in family trios. Ten family trios, each with a healthy spontaneous single-term pregnancy, were recruited.

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Background: DNA epigenetic modifications, such as methylation, are important regulators of tissue differentiation, contributing to processes of both development and cancer. Profiling the tissue-specific DNA methylome patterns will provide novel insights into normal and pathogenic mechanisms, as well as help in future epigenetic therapies. In this study, 17 somatic tissues from four autopsied humans were subjected to functional genome analysis using the Illumina Infinium HumanMethylation450 BeadChip, covering 486 428 CpG sites.

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Article Synopsis
  • - Chemosensory proteins (CSPs) are small proteins that help transport pheromones and odors, mainly found in the antennae and pheromone glands of insects like the silkworm moth.
  • - Research on RNA sequences in different tissues of adult female silkworms showed that CSPs have subtle genetic changes, with the pheromone gland displaying the highest rate of these changes (RDDs).
  • - The study found a variety of CSP protein variants specifically in the pheromone gland, suggesting that RNA editing plays a crucial role in producing diverse CSP proteins tailored to specific tissues.
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Chemosensory proteins (CSPs) are a group of small soluble proteins found so far exclusively in arthropod species. These proteins act in chemical communication and perception. In this study, a gene encoding the Type 1 CSP (BtabCSP1) from the agricultural pest Bemisia tabaci (whitefly) was analyzed to understand sequence variation and expression specificity in different biotypes.

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Two novel optical power limiters, 2-[ethyl-(4-phenylazo-phenyl)-amino]-ethanol (E4PA) and 2-[ethyl-(4-trifluoromethyl-phenylazo-phenyl)-amino]-ethanol (E4TPA) were synthesized using a diazotization reaction. The purified azo material was made into thin films in a poly(methyl methacrylate) matrix using a gravity settling technique. The electronic nonlinearities of these films were investigated using an open aperture Z-scan technique in the fs excitation regime, resulting in nonlinear absorption due to a two-photon absorption (2PA) process.

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The Autoimmune Regulator (AIRE) is a regulator of transcription in the thymic medulla, where it controls the expression of a large set of peripheral-tissue specific genes. AIRE interacts with the transcriptional coactivator and acetyltransferase CBP and synergistically cooperates with it in transcriptional activation. Here, we aimed to study a possible role of AIRE acetylation in the modulation of its activity.

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Background: Reading and writing disturbances are common accompaniments of aphasia following brain damage. However, impaired writing in the absence of apparent primary linguistic disturbances is infrequently reported in the literature.

Materials And Methods: A 67-year-old right-handed subject underwent neurological, neuroradiological, and linguistic investigations following development of a minimal right upper limb weakness.

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