Publications by authors named "Rajarshee Tagore"
RNA interference (RNAi) is a process in which small RNA molecules (such as small interfering RNAs or siRNAs) bind to specific messenger RNAs (mRNAs), leading to its degradation and inhibition of protein synthesis. Our studies have shown that RNAi can effectively silence genes involved in the replication of the Chikungunya virus (CHIKV) in cells. However, these investigations were performed only in laboratory settings and have yet to be tested in human clinical trials.
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- Chikungunya fever, caused by the chikungunya virus (CHIKV) transmitted by mosquitoes, is a significant public health issue with no available vaccines or antiviral treatments.
- Researchers propose using small interfering RNA (siRNA) to silence the virus's structural and non-structural genes as a potential antiviral treatment, which can be enhanced by effective delivery systems.
- The study demonstrates that carbonated metal-organic frameworks (specifically ZIF-C) can efficiently deliver siRNAs targeting CHIKV genes, resulting in notably decreased viral replication and infectivity in infected cells compared to standard free siRNA delivery.