Publications by authors named "Rajani R J Shelke"
Article Synopsis
- Scientists are studying how VEGFR-2, a protein important for blood vessel growth, works in the body and in diseases like cancer.
- They found that a protein called PRMT4 helps modify VEGFR-2 by adding a special chemical mark called methylation, which affects how VEGFR-2 sends signals.
- Understanding this process could help create new drugs that target VEGFR-2 to treat diseases related to blood vessel growth.
Aging may increase apoptotic events and the susceptibility of the central nervous system to apoptosis. Calorie restriction has been shown to have neuroprotective effects, but the mechanisms in vivo are unknown. We investigated apoptosis and apoptotic regulatory proteins in the brain frontal cortex of 12-month-old ad libitum fed, 26-month-old ad libitum fed, and 26-month-old calorie-restricted (CR) male Fischer 344 rats (CR = 40% restricted compared to ad libitum).
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