Publications by authors named "Rajani R Giridhar"
Discovery of anti-malarial agents through application of in silico studies.
Comb Chem High Throughput Screen
September 2015
Article Synopsis
- Malaria is the most lethal parasitic disease, and the increasing drug resistance highlights the urgent need for new effective treatments.
- In silico molecular modeling is crucial for discovering new antimalarial drugs that can combat resistant strains of the malaria parasite.
- This review summarizes advancements in computational techniques used for designing and discovering novel antimalarial compounds since 2011.
Introduction: There is an urgent need to discover new antimalarial drugs due to emergence of resistance in the parasite to the existing drugs. Malarial cysteine proteases falcipin-2 (FP-2) and falcipain-3 (FP-3) are attractive targets for antimalarial chemotherapy. The structures and functions of FP-2/3, their binding domains and their interactions with small- and macro-molecules are well studied.
View Article and Find Full Text PDF