Publications by authors named "Rajani P Brandsen"
Sickle cell retinopathy (SCR) is a complication of sickle cell disease (SCD) and can drastically impair visual acuity. Screening for SCR is therefore recommended, but evidence for optimal screening frequency on an individual level is lacking. This scoping review mapped the current evidence on risk factors for SCR and sickle cell maculopathy (SCM).
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- * A total of 249 eyes from 137 patients were examined; results showed significant macular thinning and variations in vessel density, though no clear association with the severity of SCR.
- * Despite the prevalence of macular issues, they did not lead to visual impairment, and OCTA imaging proved ineffective in predicting SCR risk in these patients.
Background: Cavernous sinus dural arteriovenous fistula (CSDAVF) is a rare condition that radiologists would encounter in their careers. We aim to describe the clinical and radiological characteristics of this condition, and to provide a management workflow.
Methods: In our retrospective study, we studied 27 patients with CSDAVF from January 2007 to August 2020.
Article Synopsis
- - Sickle cell retinopathy (SCR) is a serious eye complication linked to sickle cell disease, particularly the proliferative form (PSCR), which can cause significant vision loss.
- - In a study of 129 sickle cell disease patients over 11 years, the progression of SCR was noted in nearly 29%, with older age and specific genotypes being linked to higher risks of developing PSCR.
- - Factors such as being female, having certain genotypes, and higher levels of fetal hemoglobin (HbF) were associated with a lower risk of SCR progression, suggesting the need for tailored screening strategies based on risk levels.