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Publications by authors named "Rajani K Gaonkar"

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Effects of the antidepressant trazodone, a 5-HT 2A/2C receptor antagonist, on dopamine-dependent behaviors in rats.
Jehangir J Balsara Sujata A Jadhav Rajani K Gaonkar Ramona V Gaikwad Jagdish H Jadhav

Psychopharmacology (Berl)

May 2005

Rationale: 5-Hydroxytryptamine, via stimulation of 5-HT 2C receptors, exerts a tonic inhibitory influence on dopaminergic neurotransmission, whereas activation of 5-HT 2A receptors enhances stimulated DAergic neurotransmission. The antidepressant trazodone is a 5-HT 2A/2C receptor antagonist.

Objectives: To evaluate the effect of trazodone treatment on behaviors dependent on the functional status of the nigrostriatal DAergic system.

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