Multi-centric clinic trials in evidence-based research - A narrative review on the Indian scenario.

Evidence-based health care is gaining prominence since the past many decades. The ultimate goal of evidence-based medicine is providing the best available treatment to patients. The boom in pharmacy sector has seen a rapid rise in randomised controlled clinical trials.

Assessment of micronuclei frequency in individuals with a habit of tobacco by means of exfoliated oral buccal cells.

Aims And Objectives: To study the genotoxic effects of tobacco on the exfoliated buccal epithelial cells in patients with oral precancerous lesions (OPLs) and Patients with tobacco habit but without oral precancerous lesion(habit controls) by using micronucleus assay as well as the quantification and detection of the biomarkers in these premalignant lesions which will be helpful in finding those patients who are at higher risk for malignant transformation.

Materials And Methods: Forty samples were collected from the right and left side of buccal epithelial cells obtained from 20 individuals, i.e.

Molecular markers in oral lichen planus: A systematic review.

Oral lichen planus (OLP) is a chronic inflammatory mucosal disease that is usually detected in 0.5-2.2% of the human population.

Paracetamol induced Steven-Johnson syndrome: A rare case report.

In the contemporary era, use of drugs is the dominant paradigm of health care. The most quotidian drug used for fever and pain is paracetamol. Although adverse reactions to paracetamol in India are rare, at times they can cause life-threatening situations.