Background: The present study aimed to quantify the burden of structural heart disease in Nepali children.
Methods: We performed a school-based cross-sectional echocardiographic screening study with cluster random sampling among children 5-16 years of age.
Results: Between December 2012 and January 2019, 6573 children (mean age 10.
Introduction: Systematic echocardiographic screening of children in regions with an endemic pattern of rheumatic heart disease allows for the early detection of valvular lesions suggestive of subclinical rheumatic heart disease. The natural course of latent rheumatic heart disease is, however, incompletely understood at this time.
Methods: We performed a prospective cohort study of children detected to have echocardiographic evidence of definite or borderline rheumatic heart disease according to the World Heart Federation Criteria.
Importance: Echocardiographic screening allows for early detection of subclinical stages of rheumatic heart disease among children in endemic regions.
Objective: To investigate the effectiveness of systematic echocardiographic screening in combination with secondary antibiotic prophylaxis on the prevalence of rheumatic heart disease.
Design, Setting, And Participants: This cluster randomized clinical trial included students 9 to 16 years of age attending public and private schools in urban and rural areas of the Sunsari district in Nepal that had been randomly selected on November 17, 2012.