Comparison of five different obturation approaches for resistance against fracture in root canal treated teeth.

Endodontist should know about the fracture resistance of endodontic treated teeth in different obturation techniques to make a proper choice for obturation of mechano-chemically prepared root canals. Therefore, it is of interest to compare the fracture resistance of endodontically obturated teeth in five different obturation techniques namely single cone obturation (SCO), cold lateral compaction (CLC), cold free flow condensation, warm vertical compaction, injection molded thermo-plasticized technique. Among experimental categories, maximum fracture resistance was observed in cold free flow condensation technique while minimum fracture resistance was observed in injection molded thermo-plasticized technique.

TEX13B is essential for metabolic reprogramming during germ cell differentiation.

Study Question: What is the functional significance of Tex13b in male germ cell development and differentiation?

Summary Answer: Tex13b regulates male germ cell differentiation by metabolic reprogramming during spermatogenesis.

What Is Known Already: Studies in mice and humans suggest that TEX13B is a transcription factor and is exclusively expressed in germ cells.

Study Design, Size, Duration: We sequenced the coding regions of TEX13B in 628 infertile men and 427 ethnically matched fertile control men.

Mitochondrial Genetic Heterogeneity in Leber's Hereditary Optic Neuropathy: Original Study with Meta-Analysis.

Leber's hereditary optic neuropathy (LHON) is a mitochondrial disorder that causes loss of central vision. Three primary variants (m.3460G>A, m.

Contribution of nuclear and mitochondrial gene mutations in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome.

Background: Mitochondrial disorders are clinically complex and have highly variable phenotypes among all inherited disorders. Mutations in mitochon drial DNA (mtDNA) and nuclear genome or both have been reported in mitochondrial diseases suggesting common pathophysiological pathways. Considering the clinical heterogeneity of mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) phenotype including focal neurological deficits, it is important to look beyond mitochondrial gene mutation.

Variations in macrophage migration inhibitory factor gene are not associated with visceral leishmaniasis in India.

Background: The host genetic factors play important role in determining the outcome of visceral leishmaniasis (VL). Macrophage migration inhibitory factor (MIF) is an important host cytokine, which is a key regulator of innate immune system. Genetic variants in MIF gene have been found to be associated with several inflammatory and infectious diseases.