Publications by authors named "Rajan Gupta"

Article Synopsis
  • Biologics and small-molecule therapies have improved the treatment landscape for atopic dermatitis, but older systemic treatments are still in use.
  • The PEDIatric STudy in Atopic Dermatitis is a 10-year observational study tracking the effectiveness and safety of dupilumab, cyclosporine, and methotrexate in children under 12 with moderate-to-severe atopic dermatitis, with interim results available after 2 years.
  • Results show that dupilumab led to better improvements in skin severity, itching, and fewer discontinuations or adverse effects compared to methotrexate and cyclosporine.
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Land Use/Land Cover (LULC) dynamics provide a crucial role in the monitoring, planning, and management of resources. They also offer valuable information for developing strategies to balance conservation efforts, resolve conflicts between different land uses, and address pressures from growth. The present study focuses on the assessment of LULC dynamics, their forecasting, and their changes for Prayagraj city (including its surroundings) of India.

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Background: The distal end radius's bony anatomy in relation to three variables-Radial Inclination, Volar tilt, and radial height-has been discussed commonly in the adult population and is not very well defined in the growing skeleton. In children aged 8-16 years old, we measured the osseous distal end radius according to radiography standards. The research comprised 130 patients, 65 males and 65 females aged 8-16.

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Background: The Hip Disability and Osteoarthritis Outcome Score (HOOS JR) is a widely used patient-reported outcome measures questionnaire for total hip arthroplasty (THA). However, not all patients choose to complete HOOS JR, and thus, a subset of the THA population may be underrepresented. This study aims to investigate the association between patient demographic factors and HOOS JR response rates.

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Purpose: To compare the efficacy of a novel fusion template "reduced six-core systemic template and multiparametric magnetic resonance imaging/transrectal ultrasound (mpMRI/TRUS) fusion targeted biopsy" (TBx+6c), with mpMRI/TRUS fusion-targeted biopsy and 12-core systematic biopsy template (TBx+12c) in the diagnosis of prostate cancer (PCa).

Materials And Methods: This is an institutional review board approved single-center observational study involving adult men undergoing fusion-targeted biopsies for the diagnosis of PCa. Patients were sorted into cohorts of TBx+6c or TBx+12c based on the systematic biopsy template used.

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Multiparametric MRI is the optimal primary investigation when prostate cancer is suspected, and its ability to rule in and rule out clinically significant disease relies on high-quality anatomical and functional images. Avenues for achieving consistent high-quality acquisitions include meticulous patient preparation, scanner setup, optimised pulse sequences, personnel training, and artificial intelligence systems. The impact of these interventions on the final images needs to be quantified.

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The Knee injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS JR) is a validated patient-reported measure for assessing pain and function following total knee arthroplasty (TKA). This study investigates how patient demographic factors (i.e.

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Introduction: Neurogenic Heterotopic ossification (NHO) is a potential sequalae and a detrimental complication following neurological insult. It is characterized by formation of localized gradually progressive, peri-articular lamellar bone formation in extra-skeletal tissues. We would like to report a rare case of heterotopic ossification involving all 4 limbs, in which we tried to restore joint mobility to improve his functional status so that he could perform his daily tasks.

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Recurrent prostate cancer after primary treatment with radiation therapy is a common problem. Patients with localized recurrence may benefit from salvage therapy, but careful patient selection is crucial because not all patients will benefit from local salvage therapy, and salvage therapy has increased morbidity compared to primary treatments for prostate cancer. This review aims to provide an overview of the evaluation of patients with recurrent disease after radiation therapy and how it is continuing to evolve with increasing data on outcomes, as well as improving technologies and techniques.

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Glaciers, in general, are sensitive to changes in the climate but Himalayan glaciers, in particular, are highly affected by climate change. Mass balance (MB) of glaciers is one of the important parameters to examine the response of glaciers to climate variability and change. The study of mass balance sensitivity (MBS) due to climate perturbations for glaciers is also important to understand future behavior of the glaciers.

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Article Synopsis
  • * For pregnant patients, ultrasound is recommended to avoid radiation, while NCCT is still the go-to for those with known stone disease experiencing recurring symptoms.
  • * The American College of Radiology guidelines provide evidence-based recommendations for imaging procedures, with a focus on systematically analyzing peer-reviewed literature and expert consensus when definitive evidence is lacking.
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Prostate magnetic resonance imaging (MRI) is increasingly being used to diagnose and stage prostate cancer. The Prostate Imaging and Data Reporting System (PI-RADS) version 2.1 is a consensus-based reporting system that provides a standardized and reproducible method for interpreting prostate MRI.

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Objectives: Multiparametric magnetic resonance imaging (mpMRI) surveillance post focal cryotherapy (FT) of prostate cancer is challenging as post treatment artefacts alter mpMRI findings. In this initial experience, we assessed diagnostic performance of mpMRI in detecting clinically significant prostate cancer (csPCa) after FT.

Materials And Methods: This single-centre phase II prospective clinical trial recruited 28 men with localized csPCa for FT between October 2019 and April 2021.

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In recent years, there has been a burgeoning interest in the utilization of cyanobacteria for the purpose of land rehabilitation via enhancements in soil fertility, prevent erosion, and counter desertification. This study evaluated the ability of BOT1, sp. BOT2, and their consortia to form biocrusts on the substrate of coarse sand, fine sand, and loamy soil.

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Introduction: Idiopathic congenital talipes equinovarus (CTEV) is one of the most extensively researched topics for decades. It has been associated with various musculoskeletal anomalies which maybe bony, vascular or involving the ligaments and muscles which may have a direct or indirect impact on its pathoanatomy. This report describes an unusual presentation of a bifid tibialis anterior tendon (TAT) in a case of CTEV.

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In the recent past, various microalgae have been considered a renewable energy source for biofuel production, and their amount and extent can be enhanced by applying certain types of stress including salinity. Although microalgae growing under salinity stress result in a higher lipid content, they simultaneously reduce in growth and biomass output. To resolve this issue, the physiochemical changes in microalgae sp.

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Yoga is focused attention by breath and mantra. This forms the basis for a scientific investigation of its effect on various physiological functions such as intraocular pressure (IOP). To evaluate the effect of asanas in Yoga on the IOP of practicing individuals.

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Purpose: To evaluate the utility of the PI-QUAL score in assessing protocol changes aimed to improve image quality from a non-endorectal coil prostate MR imaging protocol during a 9-month quality improvement (QI) project and to quantify the inter-reader agreement of PI-QUAL scores between radiologists, technologists, and physicists.

Methods: This retrospective study audited 1,012 multiparametric prostate MRI examinations as part of a national QI project according to the PI-QUAL standard. PI-QUAL scores were used to inform MR protocol changes.

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The global population growth has led to a higher demand for food production, necessitating improvements in agricultural productivity. However, abiotic and biotic stresses pose significant challenges, reducing crop yields and impacting economic and social welfare. Drought, in particular, severely constrains agriculture, resulting in unproductive soil, reduced farmland, and jeopardized food security.

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Magnetic resonance imaging (MRI) has become integral to diagnosing and managing patients with suspected or confirmed prostate cancer. However, the benefits of utilizing MRI can be hindered by quality issues during imaging acquisition, interpretation, and reporting. As the utilization of prostate MRI continues to increase in clinical practice, the variability in MRI quality and how it can negatively impact patient care have become apparent.

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Purpose: PI-RADS 4 lesions are considered to have a "high" likelihood of clinically-significant prostate cancer (csPCa). However, patients undergoing targeted biopsy have a range of histologic findings. Understanding discordant cases is critical to improve diagnostic accuracy and inform subsequent management.

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