Situs Inversus Totalis (SIT) with Hepatocellular Carcinoma (HCC): A Rare Case Report and Review of 12 Other Cases.

Hepatocellular carcinoma (HCC) is the seventh-most common malignancy in males and ninth in females with incidence of one million new cases every year. Situs inversus totalis (SIT) is a rare congenital condition, in which there is a mirror-image transposition of both the abdominal and thoracic viscera. There are very few reported cases of HCC developing in people with SIT.

Laparoscopic appendicectomy in a patient with situs inversus totalis.

Situs inversus totalis (SIT) is a rare condition with a genetic predisposition, wherein organs or organ systems are transposed from their normal sites to locations on the opposite side of the body (the mirror image of normal). The syndrome may include transposition of the thoracic viscera, the abdominal viscera, or more commonly, both. The incidence has been calculated variously as 1 in 6,000-35,000 live births.

Acute small bowel obstruction due to intussusception of malignant amelonatic melanoma of the small intestine.

Malignant melanoma is a common malignancy and cutaneous melanoma showed an unusual prediction to metastasise into the small intestine. At autopsy metastatic deposits found in 50-60%, but less than 2-4% of melanoma patients diagnosed to have gastrointestinal (GI) metastasis during the disease course and 4-9% GI melanoma had unknown primary melanoma, which should be considered metastatic because primary lesion may be very small to diagnose or had regressed spontaneously. Few cases reported to have intussusception as a presenting feature.